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Review
. 2024 Apr;113(4):670-676.
doi: 10.1111/apa.17119. Epub 2024 Jan 19.

Use of transcriptomics for diagnosis of infections and sepsis in children: A narrative review

Francesca Casini  1 , Maria Sole Valentino  2 , Marc Garcia Lorenzo  2 , Roberta Caiazzo  2 , Crescenzo Coppola  2 , Daniela David  2 , Raffaella Di Tonno  2 , Vania Giacomet  2
Affiliations
Review

Use of transcriptomics for diagnosis of infections and sepsis in children: A narrative review

Francesca Casini et al. Acta Paediatr. 2024 Apr.

Abstract

Aim: The aim of this review was to summarise the most recent evidence about the use of omics-based techniques as an instrument for a more rapid and accurate characterisation of respiratory tract infections, neurological infections and sepsis in paediatrics.

Methods: We performed a narrative review using PubMed and a set of inclusion criteria: English language articles, clinical trials, meta-analysis and reviews including only paediatric population inherited to this topic in the last 15 years.

Results: The examined studies suggest that host gene expression signatures are an effective method to characterise the different types of infections, to distinguish infection from colonisation and, in some cases, to assess the severity of the disease in children.

Conclusions: 'Omics-based techniques' may help to define the aetiology of infections in paediatrics, representing a useful tool to choose the most appropriate therapies and limit antibiotic resistance.

Keywords: children; neurological infection; omics; respiratory infection; sepsis.

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References

REFERENCES

    1. Tsalik EL, Henao R, Montgomery JL, et al. Discriminating bacterial and viral infection using a rapid host gene expression test. Crit Care Med. 2021;49:1651-1663.
    1. Tamma PD, Avdic E, Li DX, Dzintars K, Cosgrove SE. Association of Adverse Events with Antibiotic use in hospitalized patients. JAMA Intern Med. 2017;177:1308-1315.
    1. Hu X, Yu J, Crosby SD, Storch GA. Gene expression profiles in febrile children with defined viral and bacterial infection. Proc Natl Acad Sci U S A. 2013;110:12792-12797.
    1. Suarez NM, Bunsow E, Falsey AR, Walsh EE, Mejias A, Ramilo O. Superiority of transcriptional profiling over procalcitonin for distinguishing bacterial from viral lower respiratory tract infections in hospitalized adults. J Infect Dis. 2015;212:213-222.
    1. Ramilo O, Allman W, Chung W, et al. Gene expression patterns in blood leukocytes discriminate patients with acute infections. Blood. 2007;109:2066-2077.

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