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. 2024 Aug;274(5):1237-1240.
doi: 10.1007/s00406-023-01742-3. Epub 2024 Jan 20.

Specific association between retinal neural layer thinning and neurological soft signs in schizophrenia

Paweł Krukow  1 , Adam Domagała  2 , Steven M Silverstein  3
Affiliations

Specific association between retinal neural layer thinning and neurological soft signs in schizophrenia

Paweł Krukow et al. Eur Arch Psychiatry Clin Neurosci. 2024 Aug.

Abstract

There is growing evidence of disproportionate retinal thinning in schizophrenia, but doubts are still raised regarding its significance in the context of the neurobiology of the disease. Therefore, we examined whether these abnormalities are significantly associated with neurological soft signs (NSS) which are closely related to the risk of schizophrenia. This cross-sectional study analyzing linear correlations between variables involved 56 schizophrenia inpatients and 60 controls. The results confirmed such relationships, and only in the patient sample. In addition, retinal abnormalities and NSS were significantly correlated with duration of illness. These findings provide further evidence for linked neurodevelopmental and neurodegenerative aspects of schizophrenia.

Keywords: Brain aging; Neurological soft signs; Optical coherence tomography; Retina; Schizophrenia.

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