International Consensus Criteria for Pediatric Sepsis and Septic Shock

doi:10.1001/jama.2024.0179

. 2024 Feb 27;331(8):665-674.

doi: 10.1001/jama.2024.0179.

International Consensus Criteria for Pediatric Sepsis and Septic Shock

Luregn J Schlapbach^{1

2}, R Scott Watson^{3

4}, Lauren R Sorce^{5

6}, Andrew C Argent^{7

8}, Kusum Menon^{9

10}, Mark W Hall^{11

12}, Samuel Akech¹³, David J Albers^{14

15}, Elizabeth R Alpern^{5

16}, Fran Balamuth^{17

18}, Melania Bembea¹⁹, Paolo Biban²⁰, Enitan D Carrol²¹, Kathleen Chiotos^{22

23}, Mohammod Jobayer Chisti²⁴, Peter E DeWitt²⁵, Idris Evans^{26

27}, Cláudio Flauzino de Oliveira^{28

29}, Christopher M Horvat^{26

27}, David Inwald³⁰, Paul Ishimine³¹, Juan Camilo Jaramillo-Bustamante^{32

33}, Michael Levin^{34

35}, Rakesh Lodha³⁶, Blake Martin^{37

38}, Simon Nadel^{39

40}, Satoshi Nakagawa⁴¹, Mark J Peters^{42

43}, Adrienne G Randolph^{44

45}, Suchitra Ranjit⁴⁶, Margaret N Rebull²⁵, Seth Russell²⁵, Halden F Scott^{47

48}, Daniela Carla de Souza^{29

49

50}, Pierre Tissieres⁵¹, Scott L Weiss^{52

53}, Matthew O Wiens^{54

55}, James L Wynn⁵⁶, Niranjan Kissoon⁵⁷, Jerry J Zimmerman^{3

4}, L Nelson Sanchez-Pinto^{5

58}, Tellen D Bennett³⁷; Society of Critical Care Medicine Pediatric Sepsis Definition Task Force

Collaborators, Affiliations

Collaborators

Society of Critical Care Medicine Pediatric Sepsis Definition Task Force:
Juliane Bubeck Wardenburg

Affiliations

¹ Department of Intensive Care and Neonatology, and Children's Research Center, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland.
² Child Health Research Centre, University of Queensland, Brisbane, Australia.
³ Department of Pediatrics, University of Washington, Seattle.
⁴ Seattle Children's Research Institute and Pediatric Critical Care, Seattle Children's, Seattle, Washington.
⁵ Ann & Robert H. Lurie Children's Hospital, Chicago, Illinois.
⁶ Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
⁷ Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, Cape Town, South Africa.
⁸ University of Cape Town, Cape Town, South Africa.
⁹ Department of Pediatrics, Children's Hospital of Eastern Ontario, Canada.
¹⁰ University of Ottawa, Ontario, Canada.
¹¹ Division of Critical Care Medicine, Nationwide Children's Hospital, Columbus, Ohio.
¹² The Ohio State University College of Medicine, Columbus, Ohio.
¹³ Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Nairobi, Kenya.
¹⁴ Departments of Biomedical Informatics, Bioengineering, Biostatistics and Informatics, University of Colorado School of Medicine, Aurora.
¹⁵ Department of Biomedical Informatics, Columbia University, New York, New York.
¹⁶ Department of Pediatrics, Division of Emergency Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
¹⁷ Department of Pediatrics, University of Pennsylvania, Perelman School of Medicine, Philadelphia.
¹⁸ Division of Emergency Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
¹⁹ Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
²⁰ Pediatric Intensive Care Unit, Verona University Hospital, Verona, Italy.
²¹ University of Liverpool, Department of Clinical Infection, Microbiology and Immunology, Institute of Infection, Veterinary and Ecological Sciences, Liverpool, United Kingdom.
²² Department of Anesthesiology and Critical Care, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.
²³ Divisions of Critical Care Medicine and Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
²⁴ Intensive Care Unit, Dhaka Hospital, Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
²⁵ Department of Biomedical Informatics, University of Colorado School of Medicine, Aurora.
²⁶ Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
²⁷ Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Center, Pittsburgh, Pennsylvania.
²⁸ AMIB-Associação de Medicina Intensiva Brasileira, São Paulo, Brazil.
²⁹ LASI-Latin American Institute of Sepsis, São Paulo, Brazil.
³⁰ Paediatric Intensive Care, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.
³¹ Departments of Emergency Medicine and Pediatrics, University of California, San Diego School of Medicine, La Jolla.
³² PICU Hospital General de Medellín "Luz Castro de Gutiérrez" and Hospital Pablo Tobón Uribe, Medellín, Colombia.
³³ Red Colaborativa Pediátrica de Latinoamérica (LARed Network).
³⁴ Section of Paediatric Infectious Diseases, Department of Infectious Diseases, Imperial College London, London, United Kingdom.
³⁵ Department of Paediatrics, St Mary's Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom.
³⁶ Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
³⁷ Departments of Biomedical Informatics and Pediatrics (Division of Critical Care Medicine), University of Colorado School of Medicine and Pediatric Intensive Care Unit, Children's Hospital Colorado, Aurora.
³⁸ Pediatric Intensive Care Unit, Children's Hospital Colorado, Aurora.
³⁹ Paediatric Intensive Care, St Mary's Hospital, London, United Kingdom.
⁴⁰ Imperial College London, London, United Kingdom.
⁴¹ Critical Care Medicine, National Center for Child Health and Development, Tokyo, Japan.
⁴² University College London Great Ormond Street Institute of Child Health, London, United Kingdom.
⁴³ Great Ormond Street Hospital for Children NHS Foundation Trust and NIHR Biomedical Research Centre, London, United Kingdom.
⁴⁴ Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, Massachusetts.
⁴⁵ Departments of Anaesthesia and Pediatrics, Harvard Medical School, Boston, Massachusetts.
⁴⁶ Pediatric Intensive Care Unit, Apollo Children's Hospital, Chennai, India.
⁴⁷ Section of Pediatric Emergency Medicine, Department of Pediatrics, University of Colorado School of Medicine, Aurora.
⁴⁸ Emergency Department, Children's Hospital Colorado, Aurora.
⁴⁹ Department of Pediatrics (PICU), Hospital Universitario of the University of São Paulo, São Paulo, Brazil.
⁵⁰ Department of Pediatrics (PICU), Hospital Sírio Libanês, São Paulo, Brazil.
⁵¹ Pediatric Intensive Care, AP-HP Paris Saclay University, Bicêtre Hospital, Le Kremlin-Bicêtre, France.
⁵² Division of Critical Care, Department of Pediatrics, Nemours Children's Health, Wilmington, Delaware.
⁵³ Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, Pennsylvania.
⁵⁴ Department of Anesthesiology, Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
⁵⁵ Institute for Global Health, BC Children's Hospital, Vancouver, Canada and Walimu, Uganda.
⁵⁶ Department of Pediatrics, University of Florida, Gainesville.
⁵⁷ Department of Pediatrics, University of British Columbia, Vancouver, Canada.
⁵⁸ Department of Pediatrics, Division of Critical Care, and Department of Preventive Medicine, Division of Health & Biomedical Informatics, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

PMID: 38245889
PMCID: PMC10900966
DOI: 10.1001/jama.2024.0179

International Consensus Criteria for Pediatric Sepsis and Septic Shock

Luregn J Schlapbach et al. JAMA. 2024.

. 2024 Feb 27;331(8):665-674.

doi: 10.1001/jama.2024.0179.

Authors

Collaborators

Society of Critical Care Medicine Pediatric Sepsis Definition Task Force:
Juliane Bubeck Wardenburg

Affiliations

¹ Department of Intensive Care and Neonatology, and Children's Research Center, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland.
² Child Health Research Centre, University of Queensland, Brisbane, Australia.
³ Department of Pediatrics, University of Washington, Seattle.
⁴ Seattle Children's Research Institute and Pediatric Critical Care, Seattle Children's, Seattle, Washington.
⁵ Ann & Robert H. Lurie Children's Hospital, Chicago, Illinois.
⁶ Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
⁷ Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, Cape Town, South Africa.
⁸ University of Cape Town, Cape Town, South Africa.
⁹ Department of Pediatrics, Children's Hospital of Eastern Ontario, Canada.
¹⁰ University of Ottawa, Ontario, Canada.
¹¹ Division of Critical Care Medicine, Nationwide Children's Hospital, Columbus, Ohio.
¹² The Ohio State University College of Medicine, Columbus, Ohio.
¹³ Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Nairobi, Kenya.
¹⁴ Departments of Biomedical Informatics, Bioengineering, Biostatistics and Informatics, University of Colorado School of Medicine, Aurora.
¹⁵ Department of Biomedical Informatics, Columbia University, New York, New York.
¹⁶ Department of Pediatrics, Division of Emergency Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
¹⁷ Department of Pediatrics, University of Pennsylvania, Perelman School of Medicine, Philadelphia.
¹⁸ Division of Emergency Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
¹⁹ Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
²⁰ Pediatric Intensive Care Unit, Verona University Hospital, Verona, Italy.
²¹ University of Liverpool, Department of Clinical Infection, Microbiology and Immunology, Institute of Infection, Veterinary and Ecological Sciences, Liverpool, United Kingdom.
²² Department of Anesthesiology and Critical Care, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.
²³ Divisions of Critical Care Medicine and Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
²⁴ Intensive Care Unit, Dhaka Hospital, Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
²⁵ Department of Biomedical Informatics, University of Colorado School of Medicine, Aurora.
²⁶ Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
²⁷ Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Center, Pittsburgh, Pennsylvania.
²⁸ AMIB-Associação de Medicina Intensiva Brasileira, São Paulo, Brazil.
²⁹ LASI-Latin American Institute of Sepsis, São Paulo, Brazil.
³⁰ Paediatric Intensive Care, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.
³¹ Departments of Emergency Medicine and Pediatrics, University of California, San Diego School of Medicine, La Jolla.
³² PICU Hospital General de Medellín "Luz Castro de Gutiérrez" and Hospital Pablo Tobón Uribe, Medellín, Colombia.
³³ Red Colaborativa Pediátrica de Latinoamérica (LARed Network).
³⁴ Section of Paediatric Infectious Diseases, Department of Infectious Diseases, Imperial College London, London, United Kingdom.
³⁵ Department of Paediatrics, St Mary's Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom.
³⁶ Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
³⁷ Departments of Biomedical Informatics and Pediatrics (Division of Critical Care Medicine), University of Colorado School of Medicine and Pediatric Intensive Care Unit, Children's Hospital Colorado, Aurora.
³⁸ Pediatric Intensive Care Unit, Children's Hospital Colorado, Aurora.
³⁹ Paediatric Intensive Care, St Mary's Hospital, London, United Kingdom.
⁴⁰ Imperial College London, London, United Kingdom.
⁴¹ Critical Care Medicine, National Center for Child Health and Development, Tokyo, Japan.
⁴² University College London Great Ormond Street Institute of Child Health, London, United Kingdom.
⁴³ Great Ormond Street Hospital for Children NHS Foundation Trust and NIHR Biomedical Research Centre, London, United Kingdom.
⁴⁴ Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, Massachusetts.
⁴⁵ Departments of Anaesthesia and Pediatrics, Harvard Medical School, Boston, Massachusetts.
⁴⁶ Pediatric Intensive Care Unit, Apollo Children's Hospital, Chennai, India.
⁴⁷ Section of Pediatric Emergency Medicine, Department of Pediatrics, University of Colorado School of Medicine, Aurora.
⁴⁸ Emergency Department, Children's Hospital Colorado, Aurora.
⁴⁹ Department of Pediatrics (PICU), Hospital Universitario of the University of São Paulo, São Paulo, Brazil.
⁵⁰ Department of Pediatrics (PICU), Hospital Sírio Libanês, São Paulo, Brazil.
⁵¹ Pediatric Intensive Care, AP-HP Paris Saclay University, Bicêtre Hospital, Le Kremlin-Bicêtre, France.
⁵² Division of Critical Care, Department of Pediatrics, Nemours Children's Health, Wilmington, Delaware.
⁵³ Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, Pennsylvania.
⁵⁴ Department of Anesthesiology, Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
⁵⁵ Institute for Global Health, BC Children's Hospital, Vancouver, Canada and Walimu, Uganda.
⁵⁶ Department of Pediatrics, University of Florida, Gainesville.
⁵⁷ Department of Pediatrics, University of British Columbia, Vancouver, Canada.
⁵⁸ Department of Pediatrics, Division of Critical Care, and Department of Preventive Medicine, Division of Health & Biomedical Informatics, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

PMID: 38245889
PMCID: PMC10900966
DOI: 10.1001/jama.2024.0179

Abstract

Importance: Sepsis is a leading cause of death among children worldwide. Current pediatric-specific criteria for sepsis were published in 2005 based on expert opinion. In 2016, the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) defined sepsis as life-threatening organ dysfunction caused by a dysregulated host response to infection, but it excluded children.

Objective: To update and evaluate criteria for sepsis and septic shock in children.

Evidence review: The Society of Critical Care Medicine (SCCM) convened a task force of 35 pediatric experts in critical care, emergency medicine, infectious diseases, general pediatrics, nursing, public health, and neonatology from 6 continents. Using evidence from an international survey, systematic review and meta-analysis, and a new organ dysfunction score developed based on more than 3 million electronic health record encounters from 10 sites on 4 continents, a modified Delphi consensus process was employed to develop criteria.

Findings: Based on survey data, most pediatric clinicians used sepsis to refer to infection with life-threatening organ dysfunction, which differed from prior pediatric sepsis criteria that used systemic inflammatory response syndrome (SIRS) criteria, which have poor predictive properties, and included the redundant term, severe sepsis. The SCCM task force recommends that sepsis in children be identified by a Phoenix Sepsis Score of at least 2 points in children with suspected infection, which indicates potentially life-threatening dysfunction of the respiratory, cardiovascular, coagulation, and/or neurological systems. Children with a Phoenix Sepsis Score of at least 2 points had in-hospital mortality of 7.1% in higher-resource settings and 28.5% in lower-resource settings, more than 8 times that of children with suspected infection not meeting these criteria. Mortality was higher in children who had organ dysfunction in at least 1 of 4-respiratory, cardiovascular, coagulation, and/or neurological-organ systems that was not the primary site of infection. Septic shock was defined as children with sepsis who had cardiovascular dysfunction, indicated by at least 1 cardiovascular point in the Phoenix Sepsis Score, which included severe hypotension for age, blood lactate exceeding 5 mmol/L, or need for vasoactive medication. Children with septic shock had an in-hospital mortality rate of 10.8% and 33.5% in higher- and lower-resource settings, respectively.

Conclusions and relevance: The Phoenix sepsis criteria for sepsis and septic shock in children were derived and validated by the international SCCM Pediatric Sepsis Definition Task Force using a large international database and survey, systematic review and meta-analysis, and modified Delphi consensus approach. A Phoenix Sepsis Score of at least 2 identified potentially life-threatening organ dysfunction in children younger than 18 years with infection, and its use has the potential to improve clinical care, epidemiological assessment, and research in pediatric sepsis and septic shock around the world.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest Disclosures: Dr Schlapbach reported receiving grants from Medical Research Future Funds (MRFF), National Health and Research Council (NHMRC), NOMIS Foundation, and Swiss Personalized Health Network (SPHN) outside the submitted work. Dr Watson reported receiving support to his institution from the National Institutes of Health (NIH) and nonfinancial support from the SCCM during the conduct of the study. Dr Argent reported receiving payments for providing expert evidence for medicolegal matters in South Africa. Dr Menon reported receiving grants from the Canadian Institutes of Health Research (CIHR) funding outside the submitted work. Dr Hall reported serving on the data and safety monitoring board for Abbvie and on a subboard of the American Board of Pediatrics; receiving nonfinancial support from Sobi and Partner Therapeutics and personal fees from Kiadis Licensing that is unrelated to the submitted work. Dr Balamuth reported receiving grants from the NIH and the Children's Hospital of Philadelphia Research Institute, Global Lyme Alliance, and the Kleberg Foundation. Dr Bembea reported receiving grants from the National Institute of Child Health and Human Development (NICHD), Grifols Research, Department of Defense, and the National Heart, Lung, and Blood Institute (NHLBI) to her institution outside the submitted work. Dr Carrol reported serving on the committee for UK National Institute for Health and Care Excellence (NICE) sepsis guidelines 2016 and SCCM International guidelines for pediatric sepsis. Dr Chiotos reported receiving grants from Centers for Disease Control and Prevention (CDC) and the Agency for Healthcare Research and Quality (AHRQ) outside the submitted work and serving as a member of the Infectious Diseases Society of America (IDSA) Sepsis Taskforce. Dr Horvat reported receiving grants from the NICHD and grants from National Institute of Neurological Disorders and Stroke (NINDS) outside the submitted work. Dr Martin reported receiving grants from the Thrasher Research Fund outside the submitted work. Dr Nakagawa reported receiving grants from the Japan Blood Products Organization outside the submitted work. Dr Peters reported receiving grants from the National Institute of Health and Care Research UK for clinical trials from the Heath Technology Assessment, Research for Patient Benefit, and Programme Grants for Applied Research programmes outside of the submitted work. Dr Randolph reported serving as the chair of the International Sepsis Forum; receiving institutional grants from the CDC, NIH, and NIAID; serving as a section editor of UpToDate and on the advisory board of ThermoFisher Pediatric; attending a scientific advisory meeting for Volition Inc; and receiving nonfinancial support from Illumina Inc in the form of reagents to Boston Children’s Hospital outside the submitted work. Dr Scott reported receiving grants from AHRQ outside the submitted work. Dr Tissieres reported receiving grants from Baxter, honoraria from a Baxter symposium, advisory fees from Sedana, ThermoFisher, and Sanofi outside the submitted work. Dr Wynn reported serving as a consultant to Sobi outside the submitted work. Dr Zimmerman reported receiving grants from Immunexpress, research funding and personal fees and royalties from Elsevier Publishing, and royalties outside the submitted work. Dr Bennett reported receiving grants from the National Center for Advancing Translational Sciences and the NHLBI outside the submitted work. No other disclosures were reported.

Figures

See this image and copyright information in PMC

Comment in

Context and Implications of the New Pediatric Sepsis Criteria.
Carlton EF, Perry-Eaddy MA, Prescott HC. Carlton EF, et al. JAMA. 2024 Feb 27;331(8):646-649. doi: 10.1001/jama.2023.27979. JAMA. 2024. PMID: 38245890 No abstract available.
Transitioning From SIRS to Phoenix With the Updated Pediatric Sepsis Criteria-The Difficult Task of Simplifying the Complex.
Jabornisky R, Kuppermann N, González-Dambrauskas S. Jabornisky R, et al. JAMA. 2024 Feb 27;331(8):650-651. doi: 10.1001/jama.2023.27988. JAMA. 2024. PMID: 38245901 No abstract available.
Pediatric Phoenix Sepsis Score Validation Challenges in Low-Resource Settings and in the Emergency Department.
Msefula J, Kumwenda M, Calis JCJ. Msefula J, et al. JAMA. 2024 Jun 25;331(24):2134. doi: 10.1001/jama.2024.8441. JAMA. 2024. PMID: 38814623 No abstract available.
Pediatric Phoenix Sepsis Score Validation Challenges in Low-Resource Settings and in the Emergency Department.
Georgette N, Eisenberg M. Georgette N, et al. JAMA. 2024 Jun 25;331(24):2134-2135. doi: 10.1001/jama.2024.8444. JAMA. 2024. PMID: 38814630 No abstract available.

Cited by

Pediatric Sepsis - Sailing the Unchartered Waters with Omics.
Baalaaji M. Baalaaji M. Indian J Crit Care Med. 2024 Sep;28(9):818-819. doi: 10.5005/jp-journals-10071-24799. Epub 2024 Aug 31. Indian J Crit Care Med. 2024. PMID: 39360198 Free PMC article.
Utility of Metagenomic Next-Generation Sequencing for Diagnosis of Infectious Diseases in Critically Ill Immunocompromised Pediatric Patients.
Xu X, Zheng Y, Zhang X, Zhang C, Gai W, Yang Z. Xu X, et al. Infect Drug Resist. 2024 Aug 16;17:3579-3591. doi: 10.2147/IDR.S472129. eCollection 2024. Infect Drug Resist. 2024. PMID: 39165848 Free PMC article.
Paediatric systemic inflammatory response syndrome (SIRS) and the development of patient-specific therapy: ethical perspectives through experts' opinions.
Stolte F, Aleksandrova-Yankulovska S, Thiemicke P, Orzechowski M, Schuetz C, Steger F. Stolte F, et al. Front Public Health. 2024 Oct 30;12:1420297. doi: 10.3389/fpubh.2024.1420297. eCollection 2024. Front Public Health. 2024. PMID: 39540090 Free PMC article.
Resuscitation in Paediatric Septic Shock Using Vitamin C and Hydrocortisone (RESPOND): The RESPOND Randomized Controlled Trial Protocol.
Raman S, Gibbons KS, Jayashree M, Lalitha AV, Bellomo R, Blythe R, Buckley D, Butt W, Cho HJ, Cree M, de Souza DC, Erickson S, Festa M, Ganu S, George S, James EJ, Johnson K, Le Marsney R, Lister P, Pham TMT, Singh P, Venkatesh B, Wall R, Long DA, Schlapbach LJ; Resuscitation in Paediatric Septic Shock using Vitamin C and Hydrocortisone (RESPOND) Study Group and the Australian and New Zealand Intensive Care Society Paediatric Study Group (ANZICS PSG). Raman S, et al. Pediatr Crit Care Med. 2025 Mar 1;26(3):e374-e385. doi: 10.1097/PCC.0000000000003674. Epub 2024 Dec 26. Pediatr Crit Care Med. 2025. PMID: 39724024 Free PMC article.
PROGNOSTIC ACCURACY OF MACHINE LEARNING MODELS FOR IN-HOSPITAL MORTALITY AMONG CHILDREN WITH PHOENIX SEPSIS ADMITTED TO THE PEDIATRIC INTENSIVE CARE UNIT.
Moore R, Chanci D, Brown S, Ripple MJ, Bishop NR, Grunwell J, Kamaleswaran R. Moore R, et al. Shock. 2025 Jan 1;63(1):80-87. doi: 10.1097/SHK.0000000000002501. Shock. 2025. PMID: 39671551

See all "Cited by" articles

References

1. Rudd KE, Johnson SC, Agesa KM, et al. Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study. Lancet. 2020;395(10219):200-211. doi: 10.1016/S0140-6736(19)32989-7 - DOI - PMC - PubMed
1. Zimmerman JJ, Banks R, Berg RA, et al. ; Life After Pediatric Sepsis Evaluation (LAPSE) Investigators . Critical illness factors associated with long-term mortality and health-related quality of life morbidity following community-acquired pediatric septic shock. Crit Care Med. 2020;48(3):319-328. doi: 10.1097/CCM.0000000000004122 - DOI - PMC - PubMed
1. Carlton EF, Gebremariam A, Maddux AB, et al. New and progressive medical conditions after pediatric sepsis hospitalization requiring critical care. JAMA Pediatr. 2022;176(11):e223554. doi: 10.1001/jamapediatrics.2022.3554 - DOI - PMC - PubMed
1. Carlton EF, Barbaro RP, Iwashyna TJ, Prescott HC. Cost of pediatric severe sepsis hospitalizations. JAMA Pediatr. 2019;173(10):986-987. doi: 10.1001/jamapediatrics.2019.2570 - DOI - PMC - PubMed
1. Souza DC, Jaramillo-Bustamante JC, Céspedes-Lesczinsky M, et al. Challenges and health-care priorities for reducing the burden of paediatric sepsis in Latin America: a call to action. Lancet Child Adolesc Health. 2022;6(2):129-136. doi: 10.1016/S2352-4642(21)00341-2 - DOI - PubMed

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Grants and funding

LinkOut - more resources

Full Text Sources
Medical
- MedlinePlus Health Information

[1] Rudd KE, Johnson SC, Agesa KM, et al. Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study. Lancet. 2020;395(10219):200-211. doi: 10.1016/S0140-6736(19)32989-7 - DOI - PMC - PubMed

[2] Rudd KE, Johnson SC, Agesa KM, et al. Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study. Lancet. 2020;395(10219):200-211. doi: 10.1016/S0140-6736(19)32989-7 - DOI - PMC - PubMed

[3] Zimmerman JJ, Banks R, Berg RA, et al. ; Life After Pediatric Sepsis Evaluation (LAPSE) Investigators . Critical illness factors associated with long-term mortality and health-related quality of life morbidity following community-acquired pediatric septic shock. Crit Care Med. 2020;48(3):319-328. doi: 10.1097/CCM.0000000000004122 - DOI - PMC - PubMed

[4] Zimmerman JJ, Banks R, Berg RA, et al. ; Life After Pediatric Sepsis Evaluation (LAPSE) Investigators . Critical illness factors associated with long-term mortality and health-related quality of life morbidity following community-acquired pediatric septic shock. Crit Care Med. 2020;48(3):319-328. doi: 10.1097/CCM.0000000000004122 - DOI - PMC - PubMed

[5] Carlton EF, Gebremariam A, Maddux AB, et al. New and progressive medical conditions after pediatric sepsis hospitalization requiring critical care. JAMA Pediatr. 2022;176(11):e223554. doi: 10.1001/jamapediatrics.2022.3554 - DOI - PMC - PubMed

[6] Carlton EF, Gebremariam A, Maddux AB, et al. New and progressive medical conditions after pediatric sepsis hospitalization requiring critical care. JAMA Pediatr. 2022;176(11):e223554. doi: 10.1001/jamapediatrics.2022.3554 - DOI - PMC - PubMed

[7] Carlton EF, Barbaro RP, Iwashyna TJ, Prescott HC. Cost of pediatric severe sepsis hospitalizations. JAMA Pediatr. 2019;173(10):986-987. doi: 10.1001/jamapediatrics.2019.2570 - DOI - PMC - PubMed

[8] Carlton EF, Barbaro RP, Iwashyna TJ, Prescott HC. Cost of pediatric severe sepsis hospitalizations. JAMA Pediatr. 2019;173(10):986-987. doi: 10.1001/jamapediatrics.2019.2570 - DOI - PMC - PubMed

[9] Souza DC, Jaramillo-Bustamante JC, Céspedes-Lesczinsky M, et al. Challenges and health-care priorities for reducing the burden of paediatric sepsis in Latin America: a call to action. Lancet Child Adolesc Health. 2022;6(2):129-136. doi: 10.1016/S2352-4642(21)00341-2 - DOI - PubMed

[10] Souza DC, Jaramillo-Bustamante JC, Céspedes-Lesczinsky M, et al. Challenges and health-care priorities for reducing the burden of paediatric sepsis in Latin America: a call to action. Lancet Child Adolesc Health. 2022;6(2):129-136. doi: 10.1016/S2352-4642(21)00341-2 - DOI - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

International Consensus Criteria for Pediatric Sepsis and Septic Shock

Collaborators

Affiliations

International Consensus Criteria for Pediatric Sepsis and Septic Shock

Authors

Collaborators

Affiliations

Abstract

Conflict of interest statement

Figures

Comment in

Similar articles

Cited by

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical

Abstract

Conflict of interest statement

Figures

Comment in

Similar articles

Cited by

References

Publication types

MeSH terms

Related information

Grants and funding

LinkOut - more resources

Full Text Sources

Medical