Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Dec 26;31(1):145-167.
doi: 10.3390/curroncol31010010.

Key Considerations for the Treatment of Advanced Breast Cancer in Older Adults: An Expert Consensus of the Canadian Treatment Landscape

Emily B Jackson  1   2 , Lauren Curry  1   2 , Caroline Mariano  1   2 , Tina Hsu  3   4 , Sarah Cook  5   6 , Rossanna C Pezo  7   8 , Marie-France Savard  3   4 , Danielle N Desautels  9   10 , Dominique Leblanc  11 , Karen A Gelmon  1   2
Affiliations
Review

Key Considerations for the Treatment of Advanced Breast Cancer in Older Adults: An Expert Consensus of the Canadian Treatment Landscape

Emily B Jackson et al. Curr Oncol. .

Abstract

The prevalence of breast cancer amongst older adults in Canada is increasing. This patient population faces unique challenges in the management of breast cancer, as older adults often have distinct biological, psychosocial, and treatment-related considerations. This paper presents an expert consensus of the Canadian treatment landscape, focusing on key considerations for optimizing selection of systemic therapy for advanced breast cancer in older adults. This paper aims to provide evidence-based recommendations and practical guidance for healthcare professionals involved in the care of older adults with breast cancer. By recognizing and addressing the specific needs of older adults, healthcare providers can optimize treatment outcomes and improve the overall quality of care for this population.

Keywords: breast cancer; expert consensus; older adults; systemic therapy; toxicity.

PubMed Disclaimer

Conflict of interest statement

None of the Authors have any financial relationship or otherwise which influenced the content of this review article. Some authors have advisory relationships with private companies which are described below. These did not impact or contribute in any way to the manuscript. Emily Jackson: None: Lauren Curry: None; Caroline Mariano: None; Tina Hsu: advisory roles for Pfizer, Knight therapeutics, Eisai, Ipsen, Mylan, Apobiologix; Sarah Cook: None; Rossanna C. Pero: advisory roles for Pfizer, Novartis and Lilly; Marie-France Savard: Advisory roles for AstraZeneca, Lilly, Seagen, Roche, Gilead, Novartis, Knight, Merck; Danielle N Desautels: consultation/advisory roles for AstraZeneca, Merck, Gilead, Pfizer, Novartis; speaker fees: Amgen; Dominique Leblanc: consultation/advisory roles for AstraZeneca, Novartis; consultation/advisory/ speaker roles for Pfizer; Karen A Gelmon: consultation /advisory roles for AstraZeneca, Pfizer, Novartis, Seagen, Merck, Lilly, Gilead, Celcuity, City of Hope.

Figures

Figure 1
Figure 1
Approach to core considerations when assessing an older adult with cancer.
See this image and copyright information in PMC

References

    1. Poirier A.E., Ruan Y., Walter S.D., Franco E.L., Villeneuve P.J., King W.D., Volesky K.D., O’sullivan D.E., Friedenreich C.M., Brenner D.R. The future burden of cancer in Canada: Long-term cancer incidence projections 2013–2042. Cancer Epidemiol. 2019;59:199–207. doi: 10.1016/j.canep.2019.02.011. - DOI - PubMed
    1. Mohile S.G., Dale W., Somerfield M.R., Schonberg M.A., Boyd C.M., Burhenn P.S., Canin B., Cohen H.J., Holmes H.M., Hopkins J.O., et al. Practical Assessment and Management of Vulnerabilities in Older Patients Receiving Chemotherapy: ASCO Guideline for Geriatric Oncology. J. Clin. Oncol. 2018;36:2326–2347. doi: 10.1200/JCO.2018.78.8687. - DOI - PMC - PubMed
    1. Mohile S.G., Fan L., Reeve E., Jean-Pierre P., Mustian K., Peppone L., Janelsins M., Morrow G., Hall W., Dale W. Association of cancer with geriatric syndromes in older Medicare beneficiaries. J. Clin. Oncol. 2011;29:1458–1464. doi: 10.1200/JCO.2010.31.6695. - DOI - PMC - PubMed
    1. Lund J.L., Duberstein P.R., Loh K.P., Gilmore N., Plumb S., Lei L., Keil A.P., Islam J.Y., Hanson L.C., Giguere J.K., et al. Life expectancy in older adults withss advanced cancer: Evaluation of a geriatric assessment-based prognostic model. J. Geriatr. Oncol. 2022;13:176–181. doi: 10.1016/j.jgo.2021.08.009. - DOI - PMC - PubMed
    1. Soo W.K., King M.T., Pope A., Parente P., Dārziņš P., Davis I.D. Integrated Geriatric Assessment and Treatment Effectiveness (INTEGERATE) in older people with cancer starting systemic anticancer treatment in Australia: A multicentre, open-label, randomised controlled trial. Lancet Health Longev. 2022;3:e617–e627. doi: 10.1016/S2666-7568(22)00169-6. - DOI - PubMed