Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Jan 2;46(1):355-366.
doi: 10.3390/cimb46010023.

Maternal Influenza and Offspring Neurodevelopment

Marya Egorova  1 , Vladimir Egorov  1   2 , Yana Zabrodskaya  1   3
Affiliations
Review

Maternal Influenza and Offspring Neurodevelopment

Marya Egorova et al. Curr Issues Mol Biol. .

Abstract

This review examines the complex interactions between maternal influenza infection, the immune system, and the neurodevelopment of the offspring. It highlights the importance of high-quality studies to clarify the association between maternal exposure to the virus and neuropsychiatric disorders in the offspring. Additionally, it emphasizes that the development of accurate animal models is vital for studying the impact of infectious diseases during pregnancy and identifying potential therapeutic targets. By drawing attention to the complex nature of these interactions, this review underscores the need for ongoing research to improve the understanding and outcomes for pregnant women and their offspring.

Keywords: animal models; immune system; infectious diseases; maternal influenza infection; neurodevelopment; neuropsychiatric disorders; pregnancy.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
The possible mechanisms of occurrence of neurological complications during pregnancy influenza.
See this image and copyright information in PMC

References

    1. Raj R.S., Bonney E.A., Phillippe M. Influenza, Immune System, and Pregnancy. Reprod. Sci. 2014;21:1434–1451. doi: 10.1177/1933719114537720. - DOI - PMC - PubMed
    1. Ehrenstein V., Kristensen N.R., Monz B.U., Clinch B., Kenwright A., Sørensen H.T. Oseltamivir in Pregnancy and Birth Outcomes. BMC Infect. Dis. 2018;18:519. doi: 10.1186/s12879-018-3423-z. - DOI - PMC - PubMed
    1. Newsome K., Alverson C.J., Williams J., McIntyre A.F., Fine A.D., Wasserman C., Lofy K.H., Acosta M., Louie J.K., Jones-Vessey K., et al. Outcomes of Infants Born to Women with Influenza A(H1N1)Pdm09. Birth Defects Res. 2019;111:88–95. doi: 10.1002/bdr2.1445. - DOI - PMC - PubMed
    1. Liong S., Miles M.A., Mohsenipour M., Liong F., Hill-Yardin E.L., Selemidis S. Influenza A Virus Infection during Pregnancy Causes Immunological Changes in Gut-Associated Lymphoid Tissues of Offspring Mice. Am. J. Physiol.-Gastrointest. Liver Physiol. 2023;325:G230–G238. doi: 10.1152/ajpgi.00062.2023. - DOI - PMC - PubMed
    1. Silasi M., Cardenas I., Kwon J., Racicot K., Aldo P., Mor G. Viral Infections During Pregnancy. Am. J. Reprod. Immunol. 2015;73:199–213. doi: 10.1111/aji.12355. - DOI - PMC - PubMed

LinkOut - more resources