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. 2023 Dec 29;14(1):53.
doi: 10.3390/jpm14010053.

The Buzz Surrounding Precision Medicine: The Imperative of Incorporating It into Evidence-Based Medical Practice

Guido Muharremi  1 , Renald Meçani  1   2 , Taulant Muka  1
Affiliations

The Buzz Surrounding Precision Medicine: The Imperative of Incorporating It into Evidence-Based Medical Practice

Guido Muharremi et al. J Pers Med. .

Abstract

Precision medicine (PM), through the integration of omics and environmental data, aims to provide a more precise prevention, diagnosis, and treatment of disease. Currently, PM is one of the emerging approaches in modern healthcare and public health, with wide implications for health care delivery, public health policy making formulation, and entrepreneurial endeavors. In spite of its growing popularity and the buzz surrounding it, PM is still in its nascent phase, facing considerable challenges that need to be addressed and resolved for it to attain the acclaim for which it strives. In this article, we discuss some of the current methodological pitfalls of PM, including the use of big data, and provide a perspective on how these challenges can be overcome by bringing PM closer to evidence-based medicine (EBM). Furthermore, to maximize the potential of PM, we present real-world illustrations of how EBM principles can be integrated into a PM approach.

Keywords: clinical medicine; evidence-based medicine; interdisciplinary approach; meta-analysis; precision medicine; public health.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
The number of papers on ‘‘precision medicine’’ and “personalized medicine” in the PubMed database worldwide. Articles until September 2023.
Figure 2
Figure 2
The number of papers on ‘‘precision medicine’’ and “personalized medicine” in the PubMed database, categorized into subsets based on their specific focal point.
Figure 3
Figure 3
The number of registered precision medicine trials per year in the clinicaltrials.gov database worldwide. Trials registered until December 2023.
See this image and copyright information in PMC

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