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Review
. 2024 Jan 5:17:1328269.
doi: 10.3389/fncel.2023.1328269. eCollection 2023.

Neuronal dysfunction and gene modulation by non-coding RNA in Parkinson's disease and synucleinopathies

Rosaria Meccariello #  1 , Gian Carlo Bellenchi #  2   3 , Salvatore Pulcrano  2 , Sebastian Luca D'Addario  3   4   5 , Domenico Tafuri  1 , Nicola B Mercuri  3   5   6 , Ezia Guatteo  1   3   5
Affiliations
Review

Neuronal dysfunction and gene modulation by non-coding RNA in Parkinson's disease and synucleinopathies

Rosaria Meccariello et al. Front Cell Neurosci. .

Abstract

Over the last few decades, emerging evidence suggests that non-coding RNAs (ncRNAs) including long-non-coding RNA (lncRNA), microRNA (miRNA) and circular-RNA (circRNA) contribute to the molecular events underlying progressive neuronal degeneration, and a plethora of ncRNAs have been identified significantly misregulated in many neurodegenerative diseases, including Parkinson's disease and synucleinopathy. Although a direct link between neuropathology and causative candidates has not been clearly established in many cases, the contribution of ncRNAs to the molecular processes leading to cellular dysfunction observed in neurodegenerative diseases has been addressed, suggesting that they may play a role in the pathophysiology of these diseases. Aim of the present Review is to overview and discuss recent literature focused on the role of RNA-based mechanisms involved in different aspects of neuronal pathology in Parkinson's disease and synucleinopathy models.

Keywords: Parkinson’s disease; circRNA; dopamine neurons; lncRNA; miRNA; ncRNA; synucleinopathy; α-synuclein.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The authors declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. The handling editor VG declared a past co-authorship with the author NBM.

Figures

FIGURE 1
FIGURE 1
Sistematic representation of the main ncRNAs detected within the brain. See the main text for further details.
See this image and copyright information in PMC

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