Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2024 Jan 19;12(1):e5494.
doi: 10.1097/GOX.0000000000005494. eCollection 2024 Jan.

Injection-related Visual Compromise

Affiliations
Case Reports

Injection-related Visual Compromise

Alejandra Santiago Díaz et al. Plast Reconstr Surg Glob Open. .

Abstract

The global market for hyaluronic acid (HA)-based dermal fillers has experienced substantial growth, providing patients with an effective nonsurgical cosmetic option. According to the global market report, the HA dermal fillers market size is expected to grow to $8.5 billion in 2027 at an annual growth rate (CAGR) of 8.9%. However, despite their popularity, HA injections are not free of complications. Vascular occlusion, particularly involving the central retinal artery, represents a significant risk. This case report presents a 60-year-old woman who presented with binocular vertical diplopia after HA filler injection in the right tear trough area. Upon evaluation, the patient exhibited right hypertropia, suggesting right inferior rectus paresis due to vascular injury of the infraorbital artery. Prompt management with hyaluronidase and oral steroids resulted in the resolution of double vision. This case highlights the importance of recognizing potential complications during HA filler injections and emphasizes the need for early intervention to minimize adverse effects.

PubMed Disclaimer

Conflict of interest statement

The authors have no financial interests to disclose in relation to this article.

Figures

Fig. 1.
Fig. 1.
Red mark at right inferior periorbital area represents the area of injection of HA by dermatologist.
Fig. 2.
Fig. 2.
Motility examination. RHT, right hypertropia; XT, exotropia; PD, prism diopter.
Fig. 3.
Fig. 3.
Right tear trough skin ultrasound. A, B, Skin ultrasound showing hypoechoic areas corresponding to persistent HA material at the right tear trough area.

References

    1. Hönig JF, Brink U, Korabiowska M. Severe granulomatous allergic tissue reaction after hyaluronic acid injection in the treatment of facial lines and its surgical correction. J Craniofac Surg. 2003;14:197–200. - PubMed
    1. Mehta P, Kaplan JB, Zhang-Nunes S. Ischemic complications of dermal fillers. Plast Aesthet Res. 2022;9:57.
    1. Downie EM, Chen Y, Lucarelli MJ, et al. . Isolated ophthalmoplegia following filler injections to the upper face. Ophthalmic Plast Reconstr Surg. 2020;36:e152–e154. - PMC - PubMed
    1. Kim A, Kim S-H, Kim H-J, et al. . Ophthalmoplegia as a complication of cosmetic facial filler injection. Acta Ophthalmol. 2016;94:e377–e379. - PubMed
    1. Shumway CL, Motlagh M, Wade M. Anatomy, head and neck, eye extraocular muscles [Updated 2022 Oct 13]. In: StatPearls. Treasure Island, Fla.: StatPearls Publishing; 2023. - PubMed

Publication types