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Case Reports
. 2024 Jan 18;11(1):2303993.
doi: 10.1080/23320885.2024.2303993. eCollection 2024.

Pseudoangiomatous stromal hyperplasia: a rare cause of gynecomastia in men

Sarah Saoud  1 , Doha Arreyouchi  1 , Anas Ankiz  1 , Anass Haloui  2 , Nassira Karich  2 , Amal Bennani  2 , Ayat Allah Oufkir  1
Affiliations
Case Reports

Pseudoangiomatous stromal hyperplasia: a rare cause of gynecomastia in men

Sarah Saoud et al. Case Reports Plast Surg Hand Surg. .

Abstract

A 17-year-old male with chest malformation and left breast enlargement underwent surgery for gynecomastia. Histological examination revealed mammary fibrous stroma with ductal hyperplasia and features of pseudoangiomatous stromal hyperplasia. Postoperative follow-up showed no complications, but 8 months later, the patient experienced a mild recurrence with enlargement of the nipple-areolar complex. Although recommended for secondary glandular resection, the patient declined further surgery.

Keywords: PASH; gynecomastia; male breast.

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Conflict of interest statement

No potential conflict of interest was reported by the author(s).

Figures

Figure 1.
Figure 1.
From left to right: preoperative image, immediate postoperative, recurrence.
Figure 2.
Figure 2.
High power view showing pseudoangiomatous stromal hyperplasia, with multiple slit-like spaces often displaying myofibroblasts at their margins that simulate endothelial cells (40× Magnification; Hematoxylin-Eosin staining).
Figure 3.
Figure 3.
Low power view showing breast parenchyma displaying an increased number of ducts with a stromal proliferation (4× Magnification; Hematoxylin-Eosin staining).
Figure 4.
Figure 4.
High power view showing a duct lined by a three-layer epithelium (luminal, intermediate and myoepithelial), cuffed by a loose stroma. (40× Magnification; Hematoxylin-Eosin staining).
See this image and copyright information in PMC

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