Significance of Gastrokine-1 Polymorphism Rs4254535 as a Prognostic Marker and its Association with Clinical Characteristics in Chinese Lung Cancer Patients

Abstract

Background: The single nucleotide polymorphism (SNP) of Gastrokine-1 (GKN1) is associated with lung cancer but its association with prognosis is not clear. Methods: Genomic DNA was extracted from the blood samples of 888 patients with lung cancer. The association between GKN1 polymorphism rs4254535 and prognostic was analyzed by the Kaplan-Meier (KM) method, Log-rank test, and Cox proportional hazards model. Results: In females and patients diagnosed with late-stage lung cancer, the CC genotype (CC vs TT, adjusted odds ratio [HR] = 0.57, 95% Confidence Interval [CI]: 0.33-0.99, P = 0.045; HR = 0.66, 95% CI: 0.48-0.92, P = 0.014) and recessive CC genotype (CC vs TT + TC, HR = 0.55, 95% CI: 0.32-0.94, P = 0.028; HR = 0.64, 95% CI: 0.47-0.89, P = 0.006) of rs4254535 conferred a better prognosis, compared with the TT and TT + TC genotype. Rs4254535 dominate TC + CC genotype, recessive CC genotype, and C allele who were adenocarcinoma patients had a significantly better prognosis. The recessive CC genotype of non-smoking patients has a better prognosis, compared to the TT + TC genotype. Additionally, in the dominant TT + TC genotype and C allele, no family history patients had a significantly better prognosis, compared to the TT genotype. Conclusion: For lung cancer patients, GKN1 polymorphism rs4254535 may be a protective genetic marker and predicts the prognosis of lung cancer patients.

Keywords: GKN1; lung cancer; prognosis; rs4254535; single nucleotide polymorphism.

Figure 1

Impacts of GKN1 polymorphism rs4254535 on the prognosis of patients with lung cancer patients. The Kaplan-Meier survival curve analysis of the GKN1 polymorphism rs4254535 and TT genotype (A) and the recessive TT + TC genotype in female (B), the CC genotype non-smoker patients (C), and no family history patients with dominant TC + CC genotype (D) survival probability. Impacts of GKN1 polymorphism rs4254535 on the prognosis of patients with dominate TT + TC genotype (E) and CC genotype (F) who adenocarcinoma patients, the CC genotype (G) and recessive TT+TC genotype (H) patients with late-stage (stage III + IV) lung cancer.