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Multicenter Study
. 2024 Oct;38(10):1982-1987.
doi: 10.1111/jdv.19803. Epub 2024 Jan 22.

Nailfold dermoscopy predicts the absence of a capillaroscopy sclerodermic pattern: The multicentre, prospective VASCUL-R trial

Jean-Benoît Monfort  1 , Tiffany Klejtman  2 , Isabelle Lazareth  2 , Diane Kottler  3 , Sophie Blaise  4 , Bernard Imbert  4 , Guillaume Chaby  5 , Catherine Lok  5 , Hervé Maillard  6 , Nathalie Beneton  6 , Julie Journet-Tollhupp  7 , Elisa Goujon  7 , Aurélien Jacquin  8 , Emilie Tella  8 , Bassirou Mboup  9 , Eric Vicaut  9 , Patricia Senet  1 ; Groupe d'Angio‐Dermatologie de la Société Française de Dermatologie
Affiliations
Multicenter Study

Nailfold dermoscopy predicts the absence of a capillaroscopy sclerodermic pattern: The multicentre, prospective VASCUL-R trial

Jean-Benoît Monfort et al. J Eur Acad Dermatol Venereol. 2024 Oct.

Abstract

Background: Nailfold capillaroscopy is recommended to diagnose primary or secondary Raynaud's phenomenon (RP). Capillaroscopy is normal in primary RP, which is the most frequent. Screening for RP capillary anomalies with nailfold dermoscopy has been promising.

Objective: To determine whether normal nailfold dermoscopy-based on the absence of five criteria that define a sclerodermic pattern-is able to predict normal capillaroscopy with good positive-predictive value (PPV).

Methods: Prospective, 2-phase (monocentre and multicentre) study on patients at first consultation for RP undergoing nailfold video capillaroscopy (NVC) and nailfold dermoscopy by two different 'blinded' trained observers, respectively, a vascular specialist and a dermatologist, not familiar with capillaroscopy. The five criteria noted were as follows: disorganization, megacapillaries, low capillary density, avascular areas and haemorrhages.

Results: Based on 105 patients, the dermoscopy PPV for a normal NVC was 100% (p = 0.015), with 37.9% sensitivity, when no criterion was observed. Excluding haemorrhages, the PPV remained 100% (p < 0.0001), with sensitivity rising to 73.7% and 100% specificity.

Conclusions: Normal nailfold dermoscopy with the absence of four easy-to-observe criteria predicts normal NVC with an excellent PPV.

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References

REFERENCES

    1. Garner R, Kumari R, Lanyon P, Doherty M, Zhang W. Prevalence, risk factors and associations of primary Raynaud's phenomenon: systematic review and meta‐analysis of observational studies. BMJ Open. 2015;5(3):e006389.
    1. Maverakis E, Patel F, Kronenberg DG, Chung L, Fiorentino D, Allanore Y, et al. International consensus criteria for the diagnosis of Raynaud's phenomenon. J Autoimmun. 2014;48–49(3):60–65.
    1. Koenig M, Joyal F, Fritzler MJ, Roussin A, Abrahamowicz M, Boire G, et al. Autoantibodies and microvascular damage are independent predictive factors for the progression of Raynaud's phenomenon to systemic sclerosis: a twenty‐year prospective study of 586 patients, with validation of proposed criteria for early systemic sclerosis. Arthritis Rheum. 2008;58(12):3902–3912.
    1. Overbury R, Murtaugh MA, Fischer A, Frech TM. Primary care assessment of capillaroscopy abnormalities in patients with Raynaud's phenomenon. Clin Rheumatol. 2015;34(12):2135–2140.
    1. Sontheimer RD. A portable digital microphotography unit for rapid documentation of periungual nailfold capillary changes in autoimmune connective tissue diseases. J Rheumatol. 2004;31(3):539–544.

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