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. 2024 Mar 28;143(13):1310-1314.
doi: 10.1182/blood.2023023428.

CALR mutation burden in essential thrombocythemia and disease outcome

Paola Guglielmelli  1 , Natasha Szuber  2   3   4 , Naseema Gangat  5 , Giulio Capecchi  1 , Chiara Maccari  1 , Michaël Harnois  3 , Omer Karrar  5 , Maymona Abdelmagid  5 , Manjola Balliu  1 , Elena Nacca  1 , Alessandro Atanasio  1 , Ilaria Sestini  1 , Audrey Désilets  2 , Giuseppe Gaetano Loscocco  1 , Giada Rotunno  1 , Lambert Busque  2   4 , Ayalew Tefferi  5 , Alessandro Maria Vannucchi  1
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Free article

CALR mutation burden in essential thrombocythemia and disease outcome

Paola Guglielmelli et al. Blood. .
Free article

Abstract

Among 281 patients with essential thrombocythemia and calreticulin (CALR) mutation, we found a variant allele frequency of ≥60% to be associated with significantly shortened myelofibrosis-free survival, mostly apparent with CALR type-1 and CALR type-indeterminate mutations.

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