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Comment
. 2024 Feb;25(1):4-6.
doi: 10.1038/s41435-023-00233-8. Epub 2024 Jan 22.

Take my breath away-mitochondrial dysfunction drives CD8+ T cell exhaustion

Felix Clemens Richter  1   2 , Mariia Saliutina  3   4 , Ahmed N Hegazy  3   4 , Andreas Bergthaler  5   6
Affiliations
Comment

Take my breath away-mitochondrial dysfunction drives CD8+ T cell exhaustion

Felix Clemens Richter et al. Genes Immun. 2024 Feb.
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1. Genetic disruption of mitochondrial metabolism drives ROS-HIF1α dependent exhaustion programs in CD8+ T cells.
Impairment of mitochondrial fitness represents a key infliction point of CD8+ T cell exhaustion in response to viral chronic infection. This implicates drugs targeting CD8+ T cell metabolism as an important new avenue to increase immune checkpoint inhibition and CAR T cell therapies.
See this image and copyright information in PMC

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References

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