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Comment
. 2024 Jan 23;5(1):4.
doi: 10.1186/s43556-023-00166-8.

Chromosomal instability (CIN) triggers immune evasion and metastatic potential in cancer through rewired STING signalling

Mrinal K Ghosh  1 , Srija Roy  2
Affiliations
Comment

Chromosomal instability (CIN) triggers immune evasion and metastatic potential in cancer through rewired STING signalling

Mrinal K Ghosh et al. Mol Biomed. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors have no relevant financial or non-financial interests to disclose.

Figures

Fig. 1
Fig. 1
Chromosomal instability (CIN) leads to double strand DNA (dsDNA)-mediated cGAS-STING pathway activation. Context-dependent functional outcome of STING leads to either interferon (IFN) response-mediated anti-tumour immunity or ER stress response-mediated immune evasion and subsequent distant metastasis. Drugs (agonist/inhibitors) enhance treatment efficacy depending on tumour subtypes. a Acute cGAS-STING signalling promotes anti-tumour immunity through activation of transcription factors like NF-κB and IRF3. b Chronic cGAS-STING signalling leads to immune evasion through ER stress response
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Comment on

  • Non-cell-autonomous cancer progression from chromosomal instability.
    Li J, Hubisz MJ, Earlie EM, Duran MA, Hong C, Varela AA, Lettera E, Deyell M, Tavora B, Havel JJ, Phyu SM, Amin AD, Budre K, Kamiya E, Cavallo JA, Garris C, Powell S, Reis-Filho JS, Wen H, Bettigole S, Khan AJ, Izar B, Parkes EE, Laughney AM, Bakhoum SF. Li J, et al. Nature. 2023 Aug;620(7976):1080-1088. doi: 10.1038/s41586-023-06464-z. Epub 2023 Aug 23. Nature. 2023. PMID: 37612508 Free PMC article.

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