Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Jan 17;14(2):294.
doi: 10.3390/ani14020294.

Porcine Epidemic Diarrhea Virus: Etiology, Epidemiology, Antigenicity, and Control Strategies in China

Jianlin Lei  1   2 , Yongqiang Miao  2 , Wenrui Bi  2 , Chaohui Xiang  2 , Wei Li  2 , Riteng Zhang  2 , Qian Li  1 , Zengqi Yang  2
Affiliations
Review

Porcine Epidemic Diarrhea Virus: Etiology, Epidemiology, Antigenicity, and Control Strategies in China

Jianlin Lei et al. Animals (Basel). .

Abstract

Porcine epidemic diarrhea virus (PEDV) is a porcine enteric coronavirus, which is one of the main causative agents of porcine epidemic diarrhea (PED), with 100% morbidity and 80-100% mortality in neonatal piglets. Since 2010, large-scale PED caused by highly pathogenic variants of PEDV has occurred successively in China and other countries in the world, posing a great threat to the global pig industry. It has been demonstrated in many investigations that the classic attenuated vaccine strain, PEDV CV777, is insufficient to fully protect against the PEDV variants. Moreover, the maternally derived antibodies elicited by inactivated vaccines also cannot completely protect piglets from infection. In addition, feedback feeding poses a risk of periodic PEDV recurrence in pig farms, making it challenging to successfully limit the spread of PEDV in China. This review focuses on the etiology, epidemiology, antigenicity, and control strategies of PEDV in China and provides information for the formulation of effective control measures.

Keywords: antigenicity; control strategies; enteric coronavirus; epidemiology; etiology; highly pathogenic variants; porcine epidemic diarrhea virus.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Phylogenetic analysis of the PEDVs based on S gene. The S gene sequences of 64 PEDV strains worldwide were downloaded from GenBank. The tree was constructed using MEGA 7 and visualized using the Interactive Tree Of Life (iTOL) software (version 6.8.1) (accessed on 25 October 2023). The GenBank accession numbers, strain names, collection dates, and countries are shown in the trees. The blue and red dots represent GII and GI, respectively. The green dot represents the PEDV S-INDEL strains. The gray square icon at the branch represents bootstrap values of 1000 replicates.
Figure 2
Figure 2
Epidemic distribution of PEDV in provinces and cities in China before and after 2010. (A) Provinces or cities with localized prevalence of PEDV in China before 2010. (B) Provinces or cities with large-scale outbreaks of PEDV in China since 2010.
See this image and copyright information in PMC

References

    1. Drosten C., Gunther S., Preiser W., van der Werf S., Brodt H.R., Becker S., Rabenau H., Panning M., Kolesnikova L., Fouchier R.A. Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N. Engl. J. Med. 2003;348:1967–1976. doi: 10.1056/NEJMoa030747. - DOI - PubMed
    1. Zaki A.M., van Boheemen S., Bestebroer T.M., Osterhaus A.D., Fouchier R.A. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N. Engl. J. Med. 2012;367:1814–1820. doi: 10.1056/NEJMoa1211721. - DOI - PubMed
    1. Sun J., He W.T., Wang L., Lai A., Ji X., Zhai X., Li G., Suchard M.A., Tian J., Zhou J., et al. COVID-19: Epidemiology, evolution, and cross-disciplinary perspectives. Trends Mol. Med. 2020;26:483–495. doi: 10.1016/j.molmed.2020.02.008. - DOI - PMC - PubMed
    1. Wang Q., Vlasova A.N., Kenney S.P., Saif L.J. Emerging and re-emerging coronaviruses in pigs. Curr. Opin. Virol. 2019;34:39–49. doi: 10.1016/j.coviro.2018.12.001. - DOI - PMC - PubMed
    1. Lednicky J.A., Tagliamonte M.S., White S.K., Elbadry M.A., Alam M.M., Stephenson C.J., Bonny T.S., Loeb J.C., Telisma T., Chavannes S., et al. Independent infections of porcine deltacoronavirus among Haitian children. Nature. 2021;600:133–137. doi: 10.1038/s41586-021-04111-z. - DOI - PMC - PubMed

LinkOut - more resources