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Review
. 2023 Dec 30;14(1):50.
doi: 10.3390/biom14010050.

Biomolecules of Muscle Fatigue in Metabolic Myopathies

Erika Schirinzi  1 , Giulia Ricci  1 , Francesca Torri  1 , Michelangelo Mancuso  1 , Gabriele Siciliano  1
Affiliations
Review

Biomolecules of Muscle Fatigue in Metabolic Myopathies

Erika Schirinzi et al. Biomolecules. .

Abstract

Metabolic myopathies are a group of genetic disorders that affect the normal functioning of muscles due to abnormalities in metabolic pathways. These conditions result in impaired energy production and utilization within muscle cells, leading to limitations in muscle function with concomitant occurrence of related signs and symptoms, among which fatigue is one of the most frequently reported. Understanding the underlying molecular mechanisms of muscle fatigue in these conditions is challenging for the development of an effective diagnostic and prognostic approach to test targeted therapeutic interventions. This paper outlines the key biomolecules involved in muscle fatigue in metabolic myopathies, including energy substrates, enzymes, ion channels, and signaling molecules. Potential future research directions in this field are also discussed.

Keywords: biomolecules; metabolic myopathies; muscle fatigue.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Clinical red flags and diagnostic algorithm for metabolic myopathies.
See this image and copyright information in PMC

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