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. 2024 Jan 8;16(2):266.
doi: 10.3390/cancers16020266.

Impairment of Nutritional Status and Quality of Life Following Minimal-Invasive Esophagectomy-A Prospective Cohort Analysis

Grace Oberhoff  1 , Lena Schooren  1 , Florian Vondran  1 , Andreas Kroh  1 , Alexander Koch  2 , Jan Bednarsch  3 , Ulf P Neumann  3 , Sophia M Schmitz  1   3 , Patrick H Alizai  1   4
Affiliations

Impairment of Nutritional Status and Quality of Life Following Minimal-Invasive Esophagectomy-A Prospective Cohort Analysis

Grace Oberhoff et al. Cancers (Basel). .

Abstract

Minimal-invasive resection of the esophagus for esophageal cancer has led to a relevant decrease in postoperative morbidity. Postoperatively, patients still suffer from surgical and adjuvant therapy-related symptoms impairing nutrition and quality of life. The aim of this study was to evaluate the nutritional status and associated symptoms six months after esophagectomy. Patients who attended follow-up examination six months after minimal-invasive esophagectomy were included. Blood and fecal tests, quality of life surveys (QLQ-C30 and QLQ-OG25) and nutritional risk screening (NRS) were performed. Twenty-four patients participated. The mean weight loss was 11 kg. A significant decrease in vitamin B12 (737 to 467 pg/mL; p = 0.033), ferritin (302 to 126 ng/mL; p = 0.012) and haptoglobin (227 to 152 mg/dL; p = 0.025) was found. In total, 47% of the patients had an impaired pancreatic function (fecal elastase < 500 µg/g). Physical (72 to 58; p = 0.034) and social functioning (67 to 40; p = 0.022) was significantly diminished, while self-reported global health status remained stable (52 to 54). The number of patients screened and found to be in need of nutritional support according to NRS score decreased slightly (59% to 52%). After MIE, patients should be meticulously monitored for nutritional status after surgery.

Keywords: esophageal cancer; malnutrition; minimal-invasive esophagectomy; nutritional risk score; quality of life.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Flowchart of patients included in the study.
Figure 2
Figure 2
NRS scores prior to surgery.
Figure 3
Figure 3
NRS scores at follow-up.
See this image and copyright information in PMC

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