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Review
. 2023 Dec 25;14(1):34.
doi: 10.3390/life14010034.

Chronic Kidney Disease Associated with Ischemic Heart Disease: To What Extent Do Biomarkers Help?

Maria-Ruxandra Cepoi  1   2 , Stefania Teodora Duca  1   2 , Adriana Chetran  1   2 , Alexandru Dan Costache  1   3 , Marilena Renata Spiridon  2 , Irina Afrăsânie  1   2 , Sabina Andreea Leancă  1   2 , Bianca-Ana Dmour  1   4 , Iulian Theodor Matei  1   2 , Radu Stefan Miftode  1   2 , Larisa Miftode  5   6 , Cristian Sorin Prepeliuc  5   6 , Mihai Ștefan Cristian Haba  1   2 , Minerva Codruța Bădescu  1   4 , Irina Iuliana Costache  1   2
Affiliations
Review

Chronic Kidney Disease Associated with Ischemic Heart Disease: To What Extent Do Biomarkers Help?

Maria-Ruxandra Cepoi et al. Life (Basel). .

Abstract

Chronic kidney disease represents a complex and multifaceted pathology characterized by the presence of structural or functional renal anomalies associated with a persistent reduction in renal function. As the disease progresses, complications arise due to the chronic inflammatory syndrome, hydro-electrolytic disorders, and toxicity secondary to the uremic environment. Cardiovascular complications are the leading cause of death for these patients. Ischemic cardiac pathology can be both a consequence and complication of chronic kidney disease, highlighting the need to identify specific cardiorenal dysfunction biomarkers targeting pathophysiological mechanisms common to both conditions. This identification is crucial for establishing accurate diagnoses, prognoses, and risk stratifications for patients. This work is intended to elucidate the intricate relationship between chronic kidney disease and ischemic heart disease and to investigate the roles of cardiorenal biomarkers, including cardiac troponin, natriuretic peptides, galectin-3, copeptin, fibroblast growth factor 23 and its co-receptor Klotho, soluble suppression of tumorigenicity 2, and plasma growth differentiation factor 15.

Keywords: acute coronary syndrome; biomarkers; chronic kidney disease; coronary artery disease; inflammation.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Cardiorenal biomarkers. This image was created with BioRender.com (accessed on 18 November 2023).
Figure 2
Figure 2
Inhibition of ST2L-IL33 results in the sST2-IL33 interactions and effect on cardiorenal axis. This image was created with BioRender.com (accessed on 18 November 2023).
Figure 3
Figure 3
Action mechanism of FGF 23 and Klotho. This image was created with BioRender.com (accessed on 18 November 2023).
See this image and copyright information in PMC

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