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Review
. 2024 Jan 8;25(2):776.
doi: 10.3390/ijms25020776.

The Multifaceted S100B Protein: A Role in Obesity and Diabetes?

Fabrizio Michetti  1   2   3   4 , Gabriele Di Sante  5 , Maria Elisabetta Clementi  1 , Federica Valeriani  6 , Martina Mandarano  7 , Francesco Ria  8 , Rosa Di Liddo  9 , Mario Rende  5 , Vincenzo Romano Spica  6
Affiliations
Review

The Multifaceted S100B Protein: A Role in Obesity and Diabetes?

Fabrizio Michetti et al. Int J Mol Sci. .

Abstract

The S100B protein is abundant in the nervous system, mainly in astrocytes, and is also present in other districts. Among these, the adipose tissue is a site of concentration for the protein. In the light of consistent research showing some associations between S100B and adipose tissue in the context of obesity, metabolic disorders, and diabetes, this review tunes the possible role of S100B in the pathogenic processes of these disorders, which are known to involve the adipose tissue. The reported data suggest a role for adipose S100B in obesity/diabetes processes, thus putatively re-proposing the role played by astrocytic S100B in neuroinflammatory/neurodegenerative processes.

Keywords: S100B protein; adipose tissue; diabetes; obesity.

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Conflict of interest statement

Author F.M. was employed by the company Genes. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Schematic representation of the paracrine loop involving S100B between adipocytes and macrophages in the development of fatty tissue dysfunction. During obesity processes, adipocytes might release S100B, which acts in a paracrine manner, as an adipokine. In a RAGE-mediated manner, S100B upregulates in macrophages inflammatory cytokines, which, in turn, can stimulate S100B release from adipocytes thus sustaining inflammation via macrophage stimulation.
Figure 2
Figure 2
High levels of S100B are associated with several non-neurological metabolic disorders.
See this image and copyright information in PMC

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