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. 2024 Jan 1;60(1):85.
doi: 10.3390/medicina60010085.

Predictive Capabilities of Human Leukocyte Antigen-G and Galectin-13 Levels in the Amniotic Fluid and Maternal Blood for the Pregnancy Outcome

Márió Vincze  1 , János Sikovanyecz Jr  1 , András Molnár  1 , Imre Földesi  2 , Andrea Surányi  1 , Szabolcs Várbíró  1 , Gábor Németh  1 , János Sikovanyecz  1 , Zoltan Kozinszky  3
Affiliations

Predictive Capabilities of Human Leukocyte Antigen-G and Galectin-13 Levels in the Amniotic Fluid and Maternal Blood for the Pregnancy Outcome

Márió Vincze et al. Medicina (Kaunas). .

Abstract

Background and Objectives: Increasing evidence points to the significant role of the angiogenic factor levels in screening for pregnancy outcome. To examine the potential relationship between concentrations of placental protein 13 (PP13) and soluble human leukocyte antigen-G (sHLA-G) in maternal serum and amniotic fluid at 16-23 weeks of gestation and the sonographic features of pregnancy as well as pregnancy outcome. Materials and Methods: PP13 and sHLA-G in serum and amniotic fluid, fetal biometrical data, and placental volume and perfusion indices were determined in 71 euploid, singleton pregnancies. Results: The serum sHLA-G level exhibits a negative correlation with the serum PP13 level (r = -0.186, p < 0.001) and a positive correlation with the sHLA-G level in amniotic fluid (r = 0.662, p < 0.001). A significant correlation was found between serum sHLA-G level and placental volume (r = 0.142, p < 0.05) and between amniotic sHLA-G level and placental perfusion (r = -0.450, p < 0.001). A low amniotic PP13 level significantly predicted the birth weight (r = -0.102, p < 0.05), the duration of pregnancy (r = -0.155, p < 0.05), and the fetal abdominal circumference (r = -0.098, p < 0.05). Conclusions: PP13 assayed in amniotic fluid might be a potential marker of fetal growth, and sHLA-G can be an adjunct modality reflecting placental sonographic parameters.

Keywords: amniotic fluid; placental protein-13; serum; soluble human leukocyte antigen-G; sonography.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The secretion of sHLA-G in maternal serum and amniotic fluid.
Figure 2
Figure 2
The secretion of PP13 in maternal serum and amniotic fluid.
Figure 3
Figure 3
The correlation between sHLA-G concentrations in serum and amniotic fluid (p < 0.001).
See this image and copyright information in PMC

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