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Review
. 2024 Jan 16;13(2):499.
doi: 10.3390/jcm13020499.

Hypertension and Dental Implants: A Systematic Review and Meta-Analysis

Liljan Hamadé  1 , Salma El-Disoki  1 , Bruno Ramos Chrcanovic  2
Affiliations
Review

Hypertension and Dental Implants: A Systematic Review and Meta-Analysis

Liljan Hamadé et al. J Clin Med. .

Abstract

Purpose: The aim of the present systematic review was to investigate the influence of hypertension on the dental implant failure rate.

Methods: An electronic search was undertaken in four databases, plus a manual search of journals. The I2 statistic was used to check heterogeneity and the inverse-variance method was used for the meta-analysis. The estimate of relative effect for dichotomous outcome was expressed as an odds ratio (OR).

Results: The review included 24 publications. There were 4874 implants (257 failures) placed in hypertensive patients and 16,192 implants (809 failures) placed in normotensive patients. A pairwise meta-analysis showed that implants in hypertensive patients did not have a higher risk of failure than implants placed in normotensive patients (OR 1.100, p = 0.671). The log OR of implant failure between hypertensive and normotensive patients did not significantly change with the follow-up time (p = 0.824).

Conclusions: This review suggests that implants in hypertensive patients do not present higher odds of failure in comparison to normotensive patients. However, further research on this topic, with the use of more rigorous criteria to diagnose patients as being hypertensive, as well as clearer information about the pharmacological management of the condition in the patients, is recommended.

Keywords: dental implant; failure; high blood pressure; hypertension; meta-analysis; meta-regression; systematic review.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 3
Figure 3
Relationship between the log odds ratio (OR) of implant failure between hypertensive and normotensive patients and the follow-up time (in months). Every circle represents a study, and the size of the circle represents the weight of the study in the analysis. The blue line represents the fitted line plot.
Figure 1
Figure 1
Study screening process.
Figure 2
Figure 2
Forest plot for the event ‘implant failure’ [19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42].
Figure 4
Figure 4
Funnel plot.
See this image and copyright information in PMC

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