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Review
. 2024 Jan 16;13(2):508.
doi: 10.3390/jcm13020508.

Does Cataract Extraction Significantly Affect Intraocular Pressure of Glaucomatous/Hypertensive Eyes? Meta-Analysis of Literature

Andrea Pasquali  1 , Luigi Varano  1 , Nicola Ungaro  1 , Viola Tagliavini  1 , Paolo Mora  1 , Matteo Goldoni  2 , Stefano Gandolfi  1
Affiliations
Review

Does Cataract Extraction Significantly Affect Intraocular Pressure of Glaucomatous/Hypertensive Eyes? Meta-Analysis of Literature

Andrea Pasquali et al. J Clin Med. .

Abstract

Background and objectives: This study aimed to evaluate the effect of cataract extraction on intraocular pressure at 6, 12, and 24 months and their difference compared to the baseline in diverse glaucoma subtypes.

Materials and methods: We carried out research in the MEDLINE, Cochrane Library and EMBASE databases, as of April 2022 for relevant papers, filtered according to established inclusion and exclusion criteria. The meta-analysis evaluated the Mean Reduction and relative Standard Error in these subpopulations at predetermined times. A total of 41 groups (2302 eyes) were included in the systematic review. Due to the significant heterogeneity, they were analysed through a Random Effects Model.

Results: We obtained these differences from baseline: (1) Open Angle Glaucoma at 6, 12 and 24 months, respectively: -2.44 mmHg, -2.71 mmHg and -3.13 mmHg; (2) Angle Closure Glaucoma at 6, 12 and 24 months, respectively: -6.81 mmHg, -7.03 mmHg and -6.52 mmHg; (3) Pseudoexfoliation Glaucoma at 12 months: -5.30 mmHg; (4) Ocular Hypertension at 24 months: -2.27 mmHg.

Conclusions: Despite a certain variability, the reduction in ocular pressure was statistically significant at 6, 12 and 24 months in both Open Angle Glaucoma and Angle Closure Glaucoma, the latter being superior. Data for Pseudoexfoliation Glaucoma and for Ocular Hypertension are available, respectively, only at 12 months and at 24 months, both being significant.

Keywords: angle closure glaucoma; glaucoma; ocular hypertension; open angle glaucoma; phacoemulsification; pseudoexfoliation.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure A1
Figure A1
Funnel plots for bias assessment with corresponding indicators in the included studies of POAG subgroup at 6, 12 and 24 months.
Figure A2
Figure A2
Funnel plots for bias assessment with corresponding indicators in the included studies of ACG subgroup at 6, 12 and 24 months.
Figure A3
Figure A3
Funnel plot for bias assessment with corresponding indicators in the included studies of PXG subgroup at 12 months and of OH subgroup at 24 months.
Figure 1
Figure 1
Literature research flow diagram.
Figure 2
Figure 2
Forest plots meta-analysis on POAG at 6, 12 and 24 months from surgery [7,9,11,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35].
Figure 3
Figure 3
Forest plots meta-analysis on ACG at 6, 12 and 24 months from surgery [4,5,6,7,8,9,10,11,12,13,14].
Figure 4
Figure 4
Forest plots meta-analysis on PXG at 12 months and on OH at 24 months from surgery [15,16,17,18,22,29,36,37].
Figure 5
Figure 5
Bar chart of average IOP reduction in mmHg in the 4 subgroups at 6, 12 and 24 months.
See this image and copyright information in PMC

References

    1. GBD 2019 Blindness. Vision Impairment Collaborators. The Vision Loss Expert Group of the Global Burden of Disease Study Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: The Right to Sight: An analysis for the Global Burden of Disease Study. Lancet Glob. Health. 2021;9:e144–e160. doi: 10.1016/S2214-109X(20)30489-7. Erratum in Lancet Glob. Health 2021, 9, e408. - DOI - PMC - PubMed
    1. Young C.E.C., Seibold L.K., Kahook M.Y. Cataract surgery and intraocular pressure in glaucoma. Curr. Opin. Ophthalmol. 2020;31:15–22. doi: 10.1097/ICU.0000000000000623. - DOI - PubMed
    1. Liu Y.C., Wilkins M., Kim T., Malyugin B., Mehta J.S. Cataracts. Lancet. 2017;390:600–612. doi: 10.1016/S0140-6736(17)30544-5. - DOI - PubMed
    1. Azuara-Blanco A., Burr J.M., Cochran C., Ramsay C., Vale L., Foster P., Friedman D., Quayyum Z., Lai J., Nolan W., et al. The effectiveness of early lens extraction with intraocular lens implantation for the treatment of primary angle-closure glaucoma (EAGLE): Study protocol for a randomized controlled trial. Trials. 2011;12:133. doi: 10.1186/1745-6215-12-133. - DOI - PMC - PubMed
    1. Dias-Santos A., Ferreira J., Abegão Pinto L., Domingues I., Silva J.P., Cunha J.P., Reina M. Phacoemulsification versus peripheral iridotomy in the management of chronic primary angle closure: Long-term follow-up. Int. Ophthalmol. 2015;35:173–178. doi: 10.1007/s10792-014-9926-8. - DOI - PubMed

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