doi: 10.1007/BF01966202.
3H-tiotidine binding to guinea-pig cortical and striatal membranes
- PMID: 3825739
- DOI: 10.1007/BF01966202
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3H-tiotidine binding to guinea-pig cortical and striatal membranes
Agents Actions.
1986 Nov.
Abstract
3H-Tiotidine has been identified as a suitable radioligand for the H2-receptor. We have confirmed and extended structure-binding affinity studies in the guinea-pig cortex, and established a structure-binding affinity relationship consistent with the H2-receptor in guinea-pig striatum. Cimetidine-displaceable 3H-tiotidine binding was observed also in the nucleus accumbens.
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