Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2024 Jan 22;10(1):513.
doi: 10.37029/jcas.v10i1.513. eCollection 2024.

A Rare Case of Primary Malignant Melanoma of Cervical Spine Having Extramedullary Intradural Origin: A Single Case Report and Literature Review

Irfan Haider  1 , Sarah Khan  2 , Fawad Ul Qamar  1 , Yasir Inam  1 , Kashmala Gul  1 , Iftikhar Ali Rana  3
Affiliations
Case Reports

A Rare Case of Primary Malignant Melanoma of Cervical Spine Having Extramedullary Intradural Origin: A Single Case Report and Literature Review

Irfan Haider et al. J Cancer Allied Spec. .

Abstract

Introduction: Primary spinal malignant melanoma (PSMM) of extramedullary intradural origin is a rare malignant condition with limited current literature regarding its clinical course, magnetic resonance imaging (MRI) findings, treatment strategies, and outcomes.

Case discussion: This is a case report of a patient with PSMM who was treated with surgery followed by radiotherapy for his residual disease in Shaukat Khanum Memorial Trust, Pakistan. The clinical and radiological findings of this case were retrospectively analyzed using the Hospital Information System.

Practical implementations: PSMM of extramedullary intradural origin is a rare malignant tumor that shows characteristic findings on MRI. Surgical resection is the preferred treatment, and radiotherapy is useful for residual disease.

Keywords: Cervical spine; extramedullary; intradural; malignant melanoma.

PubMed Disclaimer

Conflict of interest statement

Nil.

Figures

Figure 1
Figure 1
(a) Photomicrograph shows oval to spindle-shaped tumor cells with hyperchromatic nuclei. A few areas of melanin pigmentation are also visible. (H&E, ×200). (b-d) Positive immunoreactivity for S100 protein (×200), HMB-45 (×200), and Melan-A (×200)
Figure 2
Figure 2
(a) is the sagittal view of the magnetic resonance imaging (MRI) scan of the cervical spine, while (b) is the axial view of the same. Both images display a small 8-mm area of signal void in the cervical canal, located posteriorly and almost at the midline of the C3 level (indicated by a white arrow). (c and d) show the pre- and post-radiotherapy MRI scans of the cervical spine in sagittal view
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Denaro L, Pallini R, Di Muro L, Ciampini A, Vellone V, Lauretti L, et al. Primary hemorrhagic intramedullary melanoma. Case report with emphasis on the difficult preoperative diagnosis. J Neurosurg Sci. 2007;51:181–3. - PubMed
    1. Farrokh D, Frasen P, Faverly D. MR findings of a primary intramedullary malignant melanoma:Case report and literature review. AJNR Am J Neuroradiol. 2001;22:1864–6. - PMC - PubMed
    1. Brad DJ, Giannini C, Scheithauer BW, Burger PC. Primary melanocytic neoplasms of CNS. Am J Surg Pathol. 1999;23:745–54. - PubMed
    1. Kim MS, Yoon DH, Shin DA. Primary spinal cord melanoma. J Korean Neurosurg Soc. 2010;48:157–61. - PMC - PubMed
    1. Lee CH, Moon KY, Chung CK, Kim HJ, Chang KH, Park SH, et al. Primary intradural extramedullary melanoma of the cervical spinal cord:Case report. Spine (Phila Pa 1976) 2010;35:e303–7. - PubMed

Publication types

LinkOut - more resources