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[Preprint]. 2024 Jan 2:2023.12.31.573798.
doi: 10.1101/2023.12.31.573798.

A Comprehensive Allele Specific Expression Resource for the Equine Transcriptome

Harrison D Heath, Sichong Peng, Tomasz Szmatola, Rebecca R Bellone, Theodore Kalbfleisch, Jessica L Petersen, Carrie J Finno

A Comprehensive Allele Specific Expression Resource for the Equine Transcriptome

Harrison D Heath et al. bioRxiv. .

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Abstract

Background: Allele-specific expression (ASE) analysis provides a nuanced view of cis-regulatory mechanisms affecting gene expression.

Results: In this work, we introduce and highlight the significance of an equine ASE analysis, containing integrated long- and short-read RNA sequencing data, along with insight from histone modification data, from four healthy Thoroughbreds (2 mares and 2 stallions) across 9 tissues.

Conclusions: This valuable publicly accessible resource is poised to facilitate investigations into regulatory variation in equine tissues and foster a deeper understanding of the impact of allelic imbalance in equine health and disease at the molecular level.

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