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Book

Latent Tuberculosis

Cody Price  1 , Andrew D. Nguyen  2
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Free Books & Documents
Book

Latent Tuberculosis

Cody Price et al.
Free Books & Documents

Excerpt

Mycobacterium tuberculosis is a significant human pathogen. This bacterium primarily causes pulmonary disease but can spread to involve any organ and manifest as acute, chronic, or latent infection. Tuberculosis is a global disease, but the disease burden disproportionately impacts low-income countries and vulnerable populations, including those who are homeless or unsheltered, incarcerated, or who use intravenous drugs. The financial burden of tubercular illness and treatment can consume livelihoods among these populations.

In high-income countries with a low prevalence of tuberculosis, public health interventions focus on detecting and treating patients with latent tuberculosis (TB) infection. Latent TB infection may reactivate to cause active and infectious TB disease that can spread throughout the population. Identification and characterization of individuals with latent TB infection and at risk of reactivation is imperative for public health but requires balancing the benefits of therapy with potential harms.

For a comprehensive discussion of the epidemiology, etiology, pathophysiology, histopathology, evaluation, and management of tuberculosis, please see StatPearls' companion topic, "Tuberculosis."

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Conflict of interest statement

Disclosure: Cody Price declares no relevant financial relationships with ineligible companies.

Disclosure: Andrew Nguyen declares no relevant financial relationships with ineligible companies.

References

    1. Nissapatorn V, Kuppusamy I, Anuar AK, Quek KF, Latt HM. Tuberculosis: clinical manifestations and outcomes. Southeast Asian J Trop Med Public Health. 2003;34 Suppl 2:147-52. - PubMed
    1. Munteanu I, Cioran N, van Hest R, Abubakar I, Story A, Chiotan D, de Vries G, Mahler B. Tuberculosis Surveillance in Romania Among Vulnerable Risk Groups Between 2015 and 2017. Ther Clin Risk Manag. 2022;18:439-446. - PMC - PubMed
    1. Tanimura T, Jaramillo E, Weil D, Raviglione M, Lönnroth K. Financial burden for tuberculosis patients in low- and middle-income countries: a systematic review. Eur Respir J. 2014 Jun;43(6):1763-75. - PMC - PubMed
    1. Getahun H, Matteelli A, Abubakar I, Aziz MA, Baddeley A, Barreira D, Den Boon S, Borroto Gutierrez SM, Bruchfeld J, Burhan E, Cavalcante S, Cedillos R, Chaisson R, Chee CB, Chesire L, Corbett E, Dara M, Denholm J, de Vries G, Falzon D, Ford N, Gale-Rowe M, Gilpin C, Girardi E, Go UY, Govindasamy D, D Grant A, Grzemska M, Harris R, Horsburgh CR, Ismayilov A, Jaramillo E, Kik S, Kranzer K, Lienhardt C, LoBue P, Lönnroth K, Marks G, Menzies D, Migliori GB, Mosca D, Mukadi YD, Mwinga A, Nelson L, Nishikiori N, Oordt-Speets A, Rangaka MX, Reis A, Rotz L, Sandgren A, Sañé Schepisi M, Schünemann HJ, Sharma SK, Sotgiu G, Stagg HR, Sterling TR, Tayeb T, Uplekar M, van der Werf MJ, Vandevelde W, van Kessel F, van't Hoog A, Varma JK, Vezhnina N, Voniatis C, Vonk Noordegraaf-Schouten M, Weil D, Weyer K, Wilkinson RJ, Yoshiyama T, Zellweger JP, Raviglione M. Management of latent Mycobacterium tuberculosis infection: WHO guidelines for low tuberculosis burden countries. Eur Respir J. 2015 Dec;46(6):1563-76. - PMC - PubMed
    1. PaweŁczyk J, Kremer L. The Molecular Genetics of Mycolic Acid Biosynthesis. Microbiol Spectr. 2014 Aug;2(4):MGM2-0003-2013. - PubMed

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