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Review
. 2024 Apr;204(4):1176-1177.
doi: 10.1111/bjh.19230. Epub 2024 Jan 23.

Immune thrombocytopenia (ITP) in pregnancy

James B Bussel  1   2 , Katherine A Knightly  1
Affiliations
Review

Immune thrombocytopenia (ITP) in pregnancy

James B Bussel et al. Br J Haematol. 2024 Apr.

Abstract

Immune thrombocytopenia (ITP) in pregnancy is challenging for both mother and fetus. Understanding the pathophysiology, treatments, and risks to the mother and fetus leads to proper management resulting in successful pregnancy and delivery in almost all cases.1 ITP in a pregnant woman has many similarities to ITP not in pregnancy although gestational thrombocytopenia can be confused with ITP. However, recognizing differences is instrumental in avoiding bleeding complications and toxicities of treatment. This Nutshell review focuses on the natural history of ITP in pregnancy, its treatment, and dilemmas.

Keywords: platelet immunology; pregnancy; thrombocytopenia.

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References

REFERENCES

    1. Bussel JB, Hou M, Cines DB. Management of primary immune thrombocytopenia in pregnancy. N Engl J Med. 2023;389(6):540–548. https://doi.org/10.1056/NEJMra2214617
    1. Bauer ME, Arendt K, Beilin Y, Gernsheimer T, Perez Botero J, James AH, et al. The society for obstetric anesthesia and perinatology interdisciplinary consensus statement on neuraxial procedures in obstetric patients with thrombocytopenia. Anesth Analg. 2021;132(6):1531–1544. https://doi.org/10.1213/ANE.0000000000005355
    1. Samuels P, Bussel JB, Braitman LE, Tomaski A, Druzin ML, Mennuti MT, et al. Estimation of the risk of thrombocytopenia in the offspring of pregnant women with presumed immune thrombocytopenic purpura. N Engl J Med. 1990;323(4):229–235. https://doi.org/10.1056/NEJM199007263230404
    1. Christiaens GC, Nieuwenhuis HK, Bussel JB. Comparison of platelet counts in first and second newborns of mothers with immune thrombocytopenic purpura. Obstet Gynecol. 1997;90(4 Pt 1):546–552. https://doi.org/10.1016/s0029‐7844(97)00349‐9
    1. Burrows RF, Kelton JG. Fetal thrombocytopenia and its relation to maternal thrombocytopenia. N Engl J Med. 1993;329(20):1463–1466. https://doi.org/10.1056/NEJM199311113292005

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