Immune thrombocytopenia (ITP) in pregnancy
- PMID: 38263610
- DOI: 10.1111/bjh.19230
Immune thrombocytopenia (ITP) in pregnancy
Abstract
Immune thrombocytopenia (ITP) in pregnancy is challenging for both mother and fetus. Understanding the pathophysiology, treatments, and risks to the mother and fetus leads to proper management resulting in successful pregnancy and delivery in almost all cases.1 ITP in a pregnant woman has many similarities to ITP not in pregnancy although gestational thrombocytopenia can be confused with ITP. However, recognizing differences is instrumental in avoiding bleeding complications and toxicities of treatment. This Nutshell review focuses on the natural history of ITP in pregnancy, its treatment, and dilemmas.
Keywords: platelet immunology; pregnancy; thrombocytopenia.
© 2024 British Society for Haematology and John Wiley & Sons Ltd.
Similar articles
-
Low neonatal risk of thrombocytopenia in pregnancy associated with immune thrombocytopenic purpura.Fetal Diagn Ther. 1999 Jul-Aug;14(4):216-9. doi: 10.1159/000020924. Fetal Diagn Ther. 1999. PMID: 10420044
-
Idiopathic thrombocytopenic purpura complicating pregnancy.Blood Rev. 2002 Mar;16(1):43-6. doi: 10.1054/blre.2001.0181. Blood Rev. 2002. PMID: 11913994 Review.
-
[Clinical analysis of pregnancy complicated with severe thrombocytopenia].Zhonghua Fu Chan Ke Za Zhi. 2010 Jun;45(6):401-5. Zhonghua Fu Chan Ke Za Zhi. 2010. PMID: 21029587 Chinese.
-
Therapeutic approaches to secondary immune thrombocytopenic purpura.Semin Hematol. 2009 Jan;46(1 Suppl 2):S44-58. doi: 10.1053/j.seminhematol.2008.12.003. Semin Hematol. 2009. PMID: 19245934 Review.
-
Immune thrombocytopenic purpura in pregnancy: a reappraisal of obstetric management and outcome.J Reprod Med. 2011 Mar-Apr;56(3-4):163-8. J Reprod Med. 2011. PMID: 21542536
Cited by
-
Comparative analysis of thrombocytopenia incidence in patients treated with generic vs. brand-name linezolid: a cohort study utilizing hospital electronic medical records.Front Pharmacol. 2025 Jun 18;16:1528633. doi: 10.3389/fphar.2025.1528633. eCollection 2025. Front Pharmacol. 2025. PMID: 40606612 Free PMC article.
-
Detection of Thrombosis Using Soluble C-Type Lectin-like Receptor-2 with D-Dimer Level and Platelet Count.J Clin Med. 2024 Oct 8;13(19):5980. doi: 10.3390/jcm13195980. J Clin Med. 2024. PMID: 39408040 Free PMC article.
-
Hetrombopag treatment for immune thrombocytopenia in pregnancy refractory to corticosteroids and intravenous immunoglobulin: a case report.Front Med (Lausanne). 2025 Feb 18;12:1528131. doi: 10.3389/fmed.2025.1528131. eCollection 2025. Front Med (Lausanne). 2025. PMID: 40041460 Free PMC article.
References
REFERENCES
-
- Bussel JB, Hou M, Cines DB. Management of primary immune thrombocytopenia in pregnancy. N Engl J Med. 2023;389(6):540–548. https://doi.org/10.1056/NEJMra2214617
-
- Bauer ME, Arendt K, Beilin Y, Gernsheimer T, Perez Botero J, James AH, et al. The society for obstetric anesthesia and perinatology interdisciplinary consensus statement on neuraxial procedures in obstetric patients with thrombocytopenia. Anesth Analg. 2021;132(6):1531–1544. https://doi.org/10.1213/ANE.0000000000005355
-
- Samuels P, Bussel JB, Braitman LE, Tomaski A, Druzin ML, Mennuti MT, et al. Estimation of the risk of thrombocytopenia in the offspring of pregnant women with presumed immune thrombocytopenic purpura. N Engl J Med. 1990;323(4):229–235. https://doi.org/10.1056/NEJM199007263230404
-
- Christiaens GC, Nieuwenhuis HK, Bussel JB. Comparison of platelet counts in first and second newborns of mothers with immune thrombocytopenic purpura. Obstet Gynecol. 1997;90(4 Pt 1):546–552. https://doi.org/10.1016/s0029‐7844(97)00349‐9
-
- Burrows RF, Kelton JG. Fetal thrombocytopenia and its relation to maternal thrombocytopenia. N Engl J Med. 1993;329(20):1463–1466. https://doi.org/10.1056/NEJM199311113292005
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
