AllergoOncology: Biomarkers and refined classification for research in the allergy and glioma nexus-A joint EAACI-EANO position paper

Michelle C Turner^{1

2

3}, Urszula Radzikowska^{4

5}, Denisa E Ferastraoaru⁶, Mariona Pascal^{7

8

9}, Pieter Wesseling^{10

11}, Alexandra McCraw¹², Claudine Backes^{13

14}, Heather J Bax¹², Christoph Bergmann¹⁵, Rodolfo Bianchini^{16

17}, Luigi Cari¹⁸, Leticia de Las Vecillas¹⁹, Elena Izquierdo²⁰, Frida Lind-Holm Mogensen^{21

22}, Alessandro Michelucci²¹, Petr V Nazarov²³, Simone P Niclou^{22

24}, Giuseppe Nocentini¹⁸, Markus Ollert^{25

26}, Matthias Preusser²⁷, Nataliya Rohr-Udilova^{28

29}, Andrea Scafidi^{21

22}, Reka Toth²³, Mieke Van Hemelrijck³⁰, Michael Weller³¹, Uta Jappe^{32

33}, Maria M Escribese²⁰, Erika Jensen-Jarolim^{16

17}, Sophia N Karagiannis^{12

34}, Aurélie Poli²¹

Affiliations

¹ Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.
² Universitat Pompeu Fabra (UPF), Barcelona, Spain.
³ CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
⁴ Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.
⁵ Christine Kühne - Center for Allergy Research and Education (CK-CARE), Davos, Switzerland.
⁶ Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, USA.
⁷ Immunology Department, Centre de Diagnòstic Biomèdic, Hospital Clínic de Barcelona, Barcelona, Spain.
⁸ Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain.
⁹ Department of Medicine, Faculty of Medicine, Universitat de Barcelona, Barcelona, Spain.
¹⁰ Department of Pathology, Amsterdam University Medical Centers/VUmc, Amsterdam, The Netherlands.
¹¹ Laboratory for Childhood Cancer Pathology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
¹² St. John's Institute of Dermatology, School of Basic & Medical Biosciences, King's College London, Guy's Hospital, London, UK.
¹³ National Cancer Registry (Registre National du Cancer (RNC)), Luxembourg Institute of Health (LIH), Strassen, Luxembourg.
¹⁴ Public Health Expertise Unit, Department of Precision Health, Cancer Epidemiology and Prevention (EPI CAN), Luxembourg Institute of Health, Strassen, Luxembourg.
¹⁵ Department of Otorhinolaryngology, RKM740 Interdisciplinary Clinics, Düsseldorf, Germany.
¹⁶ Center of Pathophysiology, Infectiology and Immunology, Institute of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.
¹⁷ The Interuniversity Messerli Research Institute Vienna, University of Veterinary Medecine Vienna, Medical University Vienna, University Vienna, Vienna, Austria.
¹⁸ Section of Pharmacology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
¹⁹ Department of Allergy, La Paz University Hospital - IdiPAZ, Madrid, Spain.
²⁰ Institute of Applied Molecular Medicine Instituto de Medicina Molecular Aplicada Nemesio Díez (IMMA), Department of Basic Medical Sciences, Facultad de Medicina, Universidad San Pablo-CEU, CEU Universities, Madrid, Spain.
²¹ Neuro-Immunology Group, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg.
²² Faculty of Sciences, Technology and Medicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.
²³ Multiomics Data Science, Department of Cancer Research, Luxembourg Institute of Health, Strassen, Luxembourg.
²⁴ NORLUX Neuro-Oncology laboratory, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg.
²⁵ Department of Infection and Immunity, Luxembourg Institute of Health, Esch-Sur-Alzette, Luxembourg.
²⁶ Department of Dermatology and Allergy Centre, Odense University Hospital, Odense, Denmark.
²⁷ Division of Oncology, Department of Medicine I, Medical University of Vienna, Vienna, Austria.
²⁸ Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
²⁹ Liver Cancer (HCC) Study Group Vienna, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
³⁰ Translational Oncology and Urology Research (TOUR), School of Cancer and Pharmaceutical Sciences, King's College London, London, UK.
³¹ Department of Neurology, Clinical Neuroscience Center, University Hospital and University of Zurich, Zurich, Switzerland.
³² Division of Clinical and Molecular Allergology, Priority Research Area Chronic Lung Diseases, Research Center Borstel, Leibniz Lung Center, German Center for Lung Research (DZL), Airway Research Center North (ARCN), Borstel, Germany.
³³ Department of Pneumology, Interdisciplinary Allergy Outpatient Clinic, University of Luebeck, Luebeck, Germany.
³⁴ Breast Cancer Now Research Unit, School of Cancer & Pharmaceutical Sciences, King's College London, Innovation Hub, Guy's Cancer Centre, London, UK.

PMID: 38263898
DOI: 10.1111/all.15994

Review

AllergoOncology: Biomarkers and refined classification for research in the allergy and glioma nexus-A joint EAACI-EANO position paper

Michelle C Turner et al. Allergy. 2024 Jun.

. 2024 Jun;79(6):1419-1439.

doi: 10.1111/all.15994. Epub 2024 Jan 24.

Authors

Affiliations

¹ Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.
² Universitat Pompeu Fabra (UPF), Barcelona, Spain.
³ CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
⁴ Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.
⁵ Christine Kühne - Center for Allergy Research and Education (CK-CARE), Davos, Switzerland.
⁶ Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, USA.
⁷ Immunology Department, Centre de Diagnòstic Biomèdic, Hospital Clínic de Barcelona, Barcelona, Spain.
⁸ Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain.
⁹ Department of Medicine, Faculty of Medicine, Universitat de Barcelona, Barcelona, Spain.
¹⁰ Department of Pathology, Amsterdam University Medical Centers/VUmc, Amsterdam, The Netherlands.
¹¹ Laboratory for Childhood Cancer Pathology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
¹² St. John's Institute of Dermatology, School of Basic & Medical Biosciences, King's College London, Guy's Hospital, London, UK.
¹³ National Cancer Registry (Registre National du Cancer (RNC)), Luxembourg Institute of Health (LIH), Strassen, Luxembourg.
¹⁴ Public Health Expertise Unit, Department of Precision Health, Cancer Epidemiology and Prevention (EPI CAN), Luxembourg Institute of Health, Strassen, Luxembourg.
¹⁵ Department of Otorhinolaryngology, RKM740 Interdisciplinary Clinics, Düsseldorf, Germany.
¹⁶ Center of Pathophysiology, Infectiology and Immunology, Institute of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.
¹⁷ The Interuniversity Messerli Research Institute Vienna, University of Veterinary Medecine Vienna, Medical University Vienna, University Vienna, Vienna, Austria.
¹⁸ Section of Pharmacology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
¹⁹ Department of Allergy, La Paz University Hospital - IdiPAZ, Madrid, Spain.
²⁰ Institute of Applied Molecular Medicine Instituto de Medicina Molecular Aplicada Nemesio Díez (IMMA), Department of Basic Medical Sciences, Facultad de Medicina, Universidad San Pablo-CEU, CEU Universities, Madrid, Spain.
²¹ Neuro-Immunology Group, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg.
²² Faculty of Sciences, Technology and Medicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.
²³ Multiomics Data Science, Department of Cancer Research, Luxembourg Institute of Health, Strassen, Luxembourg.
²⁴ NORLUX Neuro-Oncology laboratory, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg.
²⁵ Department of Infection and Immunity, Luxembourg Institute of Health, Esch-Sur-Alzette, Luxembourg.
²⁶ Department of Dermatology and Allergy Centre, Odense University Hospital, Odense, Denmark.
²⁷ Division of Oncology, Department of Medicine I, Medical University of Vienna, Vienna, Austria.
²⁸ Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
²⁹ Liver Cancer (HCC) Study Group Vienna, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
³⁰ Translational Oncology and Urology Research (TOUR), School of Cancer and Pharmaceutical Sciences, King's College London, London, UK.
³¹ Department of Neurology, Clinical Neuroscience Center, University Hospital and University of Zurich, Zurich, Switzerland.
³² Division of Clinical and Molecular Allergology, Priority Research Area Chronic Lung Diseases, Research Center Borstel, Leibniz Lung Center, German Center for Lung Research (DZL), Airway Research Center North (ARCN), Borstel, Germany.
³³ Department of Pneumology, Interdisciplinary Allergy Outpatient Clinic, University of Luebeck, Luebeck, Germany.
³⁴ Breast Cancer Now Research Unit, School of Cancer & Pharmaceutical Sciences, King's College London, Innovation Hub, Guy's Cancer Centre, London, UK.

PMID: 38263898
DOI: 10.1111/all.15994

Abstract

Epidemiological studies have explored the relationship between allergic diseases and cancer risk or prognosis in AllergoOncology. Some studies suggest an inverse association, but uncertainties remain, including in IgE-mediated diseases and glioma. Allergic disease stems from a Th2-biased immune response to allergens in predisposed atopic individuals. Allergic disorders vary in phenotype, genotype and endotype, affecting their pathophysiology. Beyond clinical manifestation and commonly used clinical markers, there is ongoing research to identify novel biomarkers for allergy diagnosis, monitoring, severity assessment and treatment. Gliomas, the most common and diverse brain tumours, have in parallel undergone changes in classification over time, with specific molecular biomarkers defining glioma subtypes. Gliomas exhibit a complex tumour-immune interphase and distinct immune microenvironment features. Immunotherapy and targeted therapy hold promise for primary brain tumour treatment, but require more specific and effective approaches. Animal studies indicate allergic airway inflammation may delay glioma progression. This collaborative European Academy of Allergy and Clinical Immunology (EAACI) and European Association of Neuro-Oncology (EANO) Position Paper summarizes recent advances and emerging biomarkers for refined allergy and adult-type diffuse glioma classification to inform future epidemiological and clinical studies. Future research is needed to enhance our understanding of immune-glioma interactions to ultimately improve patient prognosis and survival.

Keywords: IgE; atopy; brain cancer; epidemiology; neuroimmunology.

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References

REFERENCES

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AllergoOncology: Biomarkers and refined classification for research in the allergy and glioma nexus-A joint EAACI-EANO position paper

Affiliations

AllergoOncology: Biomarkers and refined classification for research in the allergy and glioma nexus-A joint EAACI-EANO position paper

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