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. 2024 Jan 9:11:1282451.
doi: 10.3389/fpubh.2023.1282451. eCollection 2023.

Measurement of the burdens of neonatal disorders in 204 countries, 1990-2019: a global burden of disease-based study

Juan Xin #  1   2 , Yiwen Luo #  3 , Wanwan Xiang  1   3 , Sijing Zhu  1 , Hui Niu  1   3 , Jiayuan Feng  1   3 , Landi Sun  1   3 , Boxing Zhang  1   3 , Xihui Zhou  4 , Wenfang Yang  1
Affiliations

Measurement of the burdens of neonatal disorders in 204 countries, 1990-2019: a global burden of disease-based study

Juan Xin et al. Front Public Health. .

Abstract

Background: Neonatal disorders are facing serious public health challenges. Previous studies were based on limited data sources and had a narrow geographical scope. We aim to understand the trends of alteration in the burden of neonatal disorders from 1990 to 2019 in 204 countries and territories.

Methods: Data were investigated from the Global Burden of Disease Study 2019. First, we visualized the burden of neonatal disorders using the number of cases and the age-standardized incidence rate (ASIR), death rate (ASDR), and disability-adjusted life years (ASR-DALYs) from 1990 to 2019. Second, estimated annual percentage changes (EAPCs) were used to evaluate the temporal trends of disease burden during different periods. Finally, the sociodemographic index (SDI) and human development index (HDI) were used to determine whether there exists a correlation between socioeconomic development level, human development level, and potential burden consequences.

Results: Overall, in the past 30 years, the ASIR trends have remained relatively steady, whereas the ASDR and ASR-DALYs have declined. However, the burden of neonatal disorders varied greatly in various regions and countries. Among 21 regions, the ASIR trend had the largest increase in Central Latin America (EAPC = 0.42, 95%CI = 0.33-0.50). Conversely, the ASDR and ASR-DALYs experienced the largest decrease in Central Europe (EAPC = -5.10, 95%CI = -5.28 to 4.93) and East Asia (EAPC = -4.07, 95%CI = -4.41 to 3.73), respectively. Among 204 countries, the ASIR (EAPC = 3.35, 95%CI = 3.13-3.56) trend in Greece displayed the most significant increase, while the ASDR (EAPC = 1.26, 95%CI = 1.01-1.50) and ASR-DALYs (EAPC = 1.26, 95%CI = 1.03-1.49) trends in Dominica experienced the most substantial increase. Furthermore, there was a strong correlation between the EAPCs in ASIR, ASDR, ASR-DALYs, and SDI or HDI in 2019, with some exceptions. In addition, countries with elevated levels of HDI experienced a faster increase in ASDR and ASR-DALYs for neonatal disorders.

Conclusion: Although the burden of neonatal disorders shows a downward trend from 1990 to 2019, it is still not optimistic. It is necessary to implement a multi-pronged approach to reduce the increasing burden of neonatal disorders.

Keywords: death rate; disability-adjusted life years; global trend; incidence; neonatal disease burden.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The global disease burden of neonatal disorders in 204 countries and territories. (A) The relative change in incident cases of neonatal disorders between 1990 and 2019. (B) The ASIR of neonatal disorders in 2019. (C) The EAPC in ASIR of neonatal disorders from 1990 to 2019.
Figure 2
Figure 2
ASIR for neonatal disorders at the regional levels based on SDI in 2019 (21 GBD regions). The black line represents the expected value based on SDI and incidence rates in all locations.
Figure 3
Figure 3
The global disease burden of neonatal disorders for both genders in 204 countries and territories. (A) The relative change in DALYs of neonatal disorders between 1990 and 2019. (B) The ASR-DALYs of neonatal disorders in 2019. (C) The EAPC in ASR-DALYs of neonatal disorders from 1990 to 2019.
Figure 4
Figure 4
ASR-DALYs for neonatal disorders at the regional levels based on SDI in 2019 (21 GBD regions). The black line represents the expected value based on SDI and DALYs rates in all locations.
Figure 5
Figure 5
The association between HDI (2019) and EAPCs in ASIR, ASDR, and ASR-DALYs of neonatal disorders. (A) HDI (2019) was positively associated with EAPC in ASIR (ρ = 0.29, p < 0.001). (B) HDI (2019) was negatively associated with EAPC in ASDR (ρ = −0.42, p < 0.001). (C) HDI (2019) was negatively associated with EAPC in ASR-DALYs (ρ = −0.36, p < 0.001). The circles represent countries that were available on HDI data. The size of the circle increases with the number of cases of neonatal disorders.
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