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. 2024 Jan 19;10(2):e1575.
doi: 10.1097/TXD.0000000000001575. eCollection 2024 Feb.

Twelve Thousand Kidney Transplants Over More Than 55 Y: A Single-center Experience

Sandesh Parajuli  1   2 , Jacqueline Garonzik-Wang  2   3 , Brad C Astor  1   4 , Fahad Aziz  1   2 , Neetika Garg  1   2 , Bridget Welch  2   3 , Jon Odorico  2   3 , Joshua Mezrich  2   3 , Dixon Kaufman  2   3 , David P Foley  2   3 , Didier Mandelbrot  1   2
Affiliations

Twelve Thousand Kidney Transplants Over More Than 55 Y: A Single-center Experience

Sandesh Parajuli et al. Transplant Direct. .

Abstract

Background: Kidney transplant outcomes have dramatically improved since the first successful transplant in 1954. In its early years, kidney transplantation was viewed more skeptically. Today it is considered the treatment of choice among patients with end-stage kidney disease.

Methods: Our program performed its first kidney transplant in 1966 and recently performed our 12 000th kidney transplant. Here, we review and describe our experience with these 12 000 transplants. Transplant recipients were analyzed by decade of date of transplant: 1966-1975, 1976-1985, 1986-1995, 1996-2005, 2006-2015, and 2016-2022. Death-censored graft failure and mortality were outcomes of interest.

Results: Of 12 000 kidneys, 247 were transplanted from 1966 to 1975, 1147 from 1976 to 1985, 2194 from 1986 to 1995, 3147 from 1996 to 2005, 3046 from 2006 to 2015, and 2219 from 2016 to 2022 compared with 1966-1975, there were statistically significant and progressively lower risks of death-censored graft failure at 1 y, 5 y, and at last follow-up in all subsequent eras. Although mortality at 1 y was lower in all subsequent eras after 1986-1995, there was no difference in mortality at 5 y or the last follow-up between eras.

Conclusions: In this large cohort of 12 000 kidneys from a single center, we observed significant improvement in outcomes over time. Kidney transplantation remains a robust and ever-growing and improving field.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

FIGURE 1.
FIGURE 1.
Graft and patient survival. Continuous improvement in actual graft survival (A) and patient survival (B), among 12 000 kidney transplants.
FIGURE 2.
FIGURE 2.
Death censored graft failure. Kaplan-Meier survival curve of death censored graft failure at 1 y (A), at 5 y (B), and last follow-up (C) among 12 000 transplants.
FIGURE 3.
FIGURE 3.
Patient mortality. Kaplan Meier survival curve of patient mortality at 1 y (A), at 5 y (B), and at last follow-up (C) among 12 000 transplants.
See this image and copyright information in PMC

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