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Review
. 2024;24(14):1368-1384.
doi: 10.2174/0113895575277085231123165546.

Bioactivities and Structure-Activity Relationships of Usnic Acid Derivatives: A Review

Wen-Zhe Nie  1 , Qing-Kun Shen  1 , Zhe-Shan Quan  1 , Hong-Yan Guo  1 , Ya-Mei Li  2
Affiliations
Review

Bioactivities and Structure-Activity Relationships of Usnic Acid Derivatives: A Review

Wen-Zhe Nie et al. Mini Rev Med Chem. 2024.

Abstract

Usnic acid has a variety of biological activities, and has been widely studied in the fields of antibacterial, immune stimulation, antiviral, antifungal, anti-inflammatory and antiparasitic. Based on this, usnic acid is used as the lead compound for structural modification. In order to enhance the biological activity and solubility of usnic acid, scholars have carried out a large number of structural modifications, and found some usnic acid derivatives to be of more potential research value. In this paper, the structural modification, biological activity and structure-activity relationship of usnic acid were reviewed to provide reference for the development of usnic acid derivatives.

Keywords: Usnic acid; biological activity; nuclear translocation.; phenolic compounds; signaling pathways; structural modifications.

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