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. 2024 Mar;29(3):318-324.
doi: 10.1007/s10147-023-02457-0. Epub 2024 Jan 24.

The prognostic impact of treatment centralization in patients with testicular germ cell tumors: analysis of hospital-based cancer registry data in Japan

Shuhei Suzuki  1 , Yoshiyuki Nagumo  1 , Shuya Kandori  2 , Kousuke Kojo  1 , Satoshi Nitta  1 , Ichiro Chihara  1 , Masanobu Shiga  1 , Atsushi Ikeda  1 , Takashi Kawahara  1 , Akio Hoshi  1 , Hiromitsu Negoro  1 , Mathis J Bryan  3 , Ayako Okuyama  4   5 , Takahiro Higashi  4 , Hiroyuki Nishiyama  1
Affiliations

The prognostic impact of treatment centralization in patients with testicular germ cell tumors: analysis of hospital-based cancer registry data in Japan

Shuhei Suzuki et al. Int J Clin Oncol. 2024 Mar.

Abstract

Background: To identify the prognostic impact of treatment centralization in patients with testicular germ cell tumors (TGCT).

Methods: We used a hospital-based cancer registry data in Japan to extract seminoma and non-seminoma cases that were diagnosed in 2013, histologically confirmed, and received the first course of treatment. To compare the 5-years overall survival (OS) rates of patients stratified by institutional care volume, we performed a Cox proportional hazards regression analysis using inverse probability of treatment weighting (IPTW) method to adjust patient backgrounds.

Results: A total of 1767 TGCT patients were identified. The 5-years OS rates for stage II and III TGCT patients treated at low-volume institutions (< 7 cases) were significantly worse than high-volume institutions (≥ 7 cases) (91.2% vs. 83.4%, p = 0.012). Histological stratification revealed that 5-year OS rates for stage II and III seminoma patients in the low-volume group were significantly worse than the high-volume group (93.5% vs. 84.5%, p = 0.041). Multivariate OS analysis using an IPTW-matched cohort showed that institutional care volume was an independent prognostic factor (hazard ratio 2.13 [95% confidence interval: 1.23-3.71], p = 0.0072).

Conclusion: Our results indicate that stage II and III TGCT patients experience lower survival rates at low-volume institutions and would benefit from treatment centralization.

Keywords: Hospital-based cancer registry; Overall survival; Testicular germ cell tumor; Treatment centralization.

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