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. 2024 Apr;9(2):653-664.
doi: 10.1002/epi4.12903. Epub 2024 Jan 24.

Hypometabolic patterns are related to post-surgical seizure outcomes in focal cortical dysplasia: A semi-quantitative study

Yuan Yao  1 , Xiu Wang  1 , Baotian Zhao  1 , Jiajie Mo  1 , Zhihao Guo  1 , Bowen Yang  1 , Zilin Li  1 , Xiuliang Fan  1 , Du Cai  1 , Lin Sang  2 , Zhong Zheng  2 , Xiaoqiu Shao  3 , Lin Ai  4 , Wenhan Hu  5 , Chao Zhang  1 , Kai Zhang  1
Affiliations

Hypometabolic patterns are related to post-surgical seizure outcomes in focal cortical dysplasia: A semi-quantitative study

Yuan Yao et al. Epilepsia Open. 2024 Apr.

Abstract

Objective: Fluorine-18-fluorodeoxyglucose-positron emission tomography (FDG-PET) is routinely used for presurgical evaluation in many epilepsy centers. Hypometabolic characteristics have been extensively examined in prior studies, but the metabolic patterns associated with specific pathological types of drug-resistant epilepsy remain to be fully defined. This study was developed to explore the relationship between metabolic patterns or characteristics and surgical outcomes in type I and II focal cortical dysplasia (FCD) patients based on results from a large cohort.

Methods: Data from individuals who underwent epilepsy surgery from 2014 to 2019 with a follow-up duration of over 3 years and a pathological classification of type I or II FCD in our hospital were retrospectively analyzed. Hypometabolic patterns were quantitatively identified via statistical parametric mapping (SPM) and qualitatively analyzed via visual examination of PET-MRI co-registration images. Univariate analyses were used to explore the relationship between metabolic patterns and surgical outcomes.

Results: In total, this study included data from 210 patients. Following SPM calculations, four hypometabolic patterns were defined including unilobar, multi-lobar, and remote patterns as well as cases where no pattern was evident. In type II FCD patients, the unilobar pattern was associated with the best surgical outcomes (p = 0.014). In visual analysis, single gyrus (p = 0.032) and Clear-cut hypometabolism edge (p = 0.040) patterns exhibited better surgery outcomes in the type II FCD group.

Conclusions: PET metabolic patterns are well-correlated with the prognosis of type II FCD patients. However, similar correlations were not observed in type I FCD, potentially owing to the complex distribution of the epileptogenic region.

Plain language summary: In this study, we demonstrated that FDG-PET was a crucial examination for patients with FCD, which was a common cause of epilepsy. We compared the surgical prognosis for patients with different hypometabolism distribution patterns and found that clear and focal abnormal region in PET was correlated with good surgical outcome in type II FCD patients.

Keywords: Fluorine‐18‐fluorodeoxyglucose–positron emission tomography; focal cortical dysplasia; hypometabolism; surgery outcome.

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Conflict of interest statement

No conflict of interest exists in the submission of this manuscript. We confirm that we have read the Journal's position on issues involved in ethical publication and affirm that this report is consistent with those guidelines.

Figures

FIGURE 1
FIGURE 1
A–D, E–H, I–L: Three different patients in unilobar, multi‐lobar, and remote groups whose hypometabolic area calculated by SPM was shown in sagittal, coronal, axial, and 3D‐reconstructed brain respectively. Color bars indicate statistical T values.
FIGURE 2
FIGURE 2
A–C: Sagittal, coronal, axial PET‐MRI fusion images of one patient in the SG group. D–F: Sagittal, coronal, axial PET‐MRI fusion images of one patient in ≥2 gyri group.
FIGURE 3
FIGURE 3
A–C: PET‐MRI fusion images of one patient in a clear‐cut edge group. D–F: PET‐MRI fusion images of one patient in the non‐clear‐cut group.
See this image and copyright information in PMC

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