Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Jan 24;22(1):29.
doi: 10.1186/s12957-024-03312-w.

Risk factors and prognosis of malignant peritoneal mesothelioma with paraneoplastic syndrome

Xin-Li Liang  1 , Yan-Dong Su  1 , Xin-Bao Li  1 , Yu-Bin Fu  1 , Ru Ma  1 , Rui Yang  1 , He-Liang Wu  2 , Yan Li  3   4
Affiliations

Risk factors and prognosis of malignant peritoneal mesothelioma with paraneoplastic syndrome

Xin-Li Liang et al. World J Surg Oncol. .

Abstract

Background: Malignant peritoneal mesothelioma (MPM) is a rare and highly aggressive tumor. Its clinical manifestations are diverse, and the symptoms are not specific. Some patients will develop paraneoplastic syndrome (PS) during the disease course. This study aims to analyze the risk factors of PS in patients with MPM and their impacts on prognosis.

Methods: The clinical data of MPM patients who underwent cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy (CRS + HIPEC) at our center from June 2015 to May 2023 were retrospectively analyzed. MPM patients were divided into PS group and non-PS group according to the diagnostic criteria. Univariate and multivariate analyses were performed to explore the risk factors of PS in MPM patients, and to analyze the impact of PS on prognosis.

Results: There were 146 MPM patients in this study, including 60 patients (41.1%) with PS and 86 patients (58.9%) without PS. The highest incidence of PS was thrombocytosis (33.6%), followed by neoplastic fever (9.6%). Univariate analysis revealed 8 factors (P < 0.05) with statistically significant differences between the two groups: prior surgical scores, targeted therapy history, Karnofsky performance status score, preoperative carbohydrate antigen (CA) 125 level, vascular tumor embolus, peritoneal cancer index, completeness of cytoreduction (CC) score and intraoperative ascites. Multivariate analysis identified 3 independent factors associated with PS: preoperative CA 125 level, vascular tumor embolus, and CC score. Survival analysis demonstrated that MPM patients with PS had worse prognosis, although PS was not an independent prognostic factor.

Conclusions: PS is not rare in patients with MPM, and is independently associated with preoperative CA 125 level, vascular tumor embolus and CC score. PS often indicates advanced disease and poor prognosis.

Keywords: Malignant peritoneal mesothelioma; Neoplastic fever; Paraneoplastic syndrome; Prognosis; Thrombocytosis.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Survival analysis. A, Overall survival analysis of all patients. B, Survival curve analysis of non-PS group and PS group
Fig. 2
Fig. 2
Curves of treatment indicators. A, Temperature. B, Count of platelet. C, CA 125
Fig. 3
Fig. 3
Patient treatment flowchart
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Sun L, Li C, Gao S. Diffuse malignant peritoneal mesothelioma: a review. Front Surg. 2022;9:1015884. doi: 10.3389/fsurg.2022.1015884. - DOI - PMC - PubMed
    1. Broeckx G, Pauwels P. Malignant peritoneal mesothelioma: a review. Transl Lung Cancer Res. 2018;7(5):537–542. doi: 10.21037/tlcr.2018.10.04. - DOI - PMC - PubMed
    1. Kusamura S, Baratti D, De Simone M, et al. Diagnostic and therapeutic pathway in diffuse malignant peritoneal mesothelioma. Cancers (Basel). 2023;15(3):662. - PMC - PubMed
    1. Chun CP, Song LX, Zhang HP, et al. Malignant peritoneal mesothelioma. Am J Med Sci. 2023;365(1):99–103. doi: 10.1016/j.amjms.2022.07.008. - DOI - PubMed
    1. Malpica A. Peritoneal mesothelioma-an update. Adv Anat Pathol. 2023;30(4):262–274. doi: 10.1097/PAP.0000000000000387. - DOI - PubMed