Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Jan 23:11:2333794X231226057.
doi: 10.1177/2333794X231226057. eCollection 2024.

Effect of Serial Clinical Observation Complemented by Point-of-Care Blood Culture Volume Verification on Antibiotic Exposure in Newborns

Tomasz Wawrzoniak  1 , Justyna Romańska  1
Affiliations

Effect of Serial Clinical Observation Complemented by Point-of-Care Blood Culture Volume Verification on Antibiotic Exposure in Newborns

Tomasz Wawrzoniak et al. Glob Pediatr Health. .

Abstract

Objective. This study evaluated the effects of serial clinical observation strategy complemented by point-of-care verification of blood culture volume in managing term and near-term newborns at risk for early-onset sepsis. Methods. We used a "before-and-after" approach. Infants born at ≥35 0/7 weeks' gestation were eligible. Our strategy was based on serial clinical observation complemented with point-of-care verification of blood culture volume. Two separate 12-month periods were analyzed. The number of infants exposed to antibiotics started during the first 3 days of life was compared before and after introducing the strategy. Results. During the post-intervention period, 0.6% of infants received antibiotic therapy, compared to 4.1% during the pre-intervention period (P < .001; relative risk [RR]: 0.15; 95% CI: 0.08-0.28). Conclusion. Serial clinical observation complemented with verification of blood culture volume might reduce antibiotic utilization in newborns in the early postnatal period.

Keywords: antibiotic utilization; blood culture; neonatal early-onset sepsis; newborn; serial clinical observation.

PubMed Disclaimer

Conflict of interest statement

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Flow diagram of the study.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Puopolo KM, Benitz WE, Zaoutis TE, Committee on Fetus and Newborn, Committee on Infectious Diseases. Management of neonates born at ≥35 0/7 weeks’ gestation with suspected or proven early-onset bacterial sepsis. Pediatrics. 2018;142(6):e20182894. doi:10.1542/peds.2018-2894 - DOI - PubMed
    1. Joshi NS, Gupta A, Allan JM, et al.. Clinical Monitoring of Well-Appearing Infants Born to Mothers With Chorioamnionitis. Pediatrics. 2018;141(4):e20172056. doi:10.1542/peds.2017-2056 - DOI - PubMed
    1. Fjalstad JW, Stensvold HJ, Bergseng H, et al.. (2016). Early-onset sepsis and antibiotic exposure in term infants: a nationwide population-based study in Norway. Pediatr infect Dis J. 2016;35(1):1-6. doi:10.1097/INF.0000000000000906 - DOI - PubMed
    1. Ficara M, Pietrella E, Spada C, et al.. (2020). Changes of intestinal microbiota in early life. J Matern Fetal Neonatal Med. 2020;33(6):1036-1043. doi:10.1080/14767058.2018.1506760 - DOI - PubMed
    1. Aires J. First 1000 days of life: consequences of antibiotics on gut microbiota. Front Microbiol. 2012;12:681427. doi:10.3389/fmicb.2021.681427 - DOI - PMC - PubMed

LinkOut - more resources