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. 2024 Jan 25;134(5):e175996.
doi: 10.1172/JCI175996.

C5 inhibition with eculizumab prevents thrombotic microangiopathy in a case series of pig-to-human kidney xenotransplantation

Maggie E Jones-Carr  1 , Huma Fatima  2 , Vineeta Kumar  3 , Douglas J Anderson  1 , Julie Houp  2 , Jackson C Perry  1 , Gavin A Baker  1 , Leigh McManus  1 , Andrew J Shunk  4 , Paige M Porrett  1 , Jayme E Locke  1
Affiliations

C5 inhibition with eculizumab prevents thrombotic microangiopathy in a case series of pig-to-human kidney xenotransplantation

Maggie E Jones-Carr et al. J Clin Invest. .
No abstract available

Keywords: Complement; Innate immunity; Nephrology; Organ transplantation; Transplantation.

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Conflict of interest statement

Conflict of interest: JEL reports consulting fees from Sanofi. JEL, HF, DJA, and PMP report grant support from United Therapeutics and subsidiaries (Revivicor and Lung Biotechnology).

Figures

Figure 1
Figure 1. Renal histology and MAC IHC after xenotransplantation of 10GE porcine kidneys using the Parsons model of human decedents.
(A) Decedent 1; no eculizumab was given. Fibrin thrombi (arrowheads), indicative of TMA. The inset images are roughly original magnification, 60×. (B and C) Decedents 2 and 3; induction eculizumab was given. Both decedents’ native kidneys were MAC+, as well as Decedent 3 xenografts on POD5 and POD7. (D) MAC controls (glomerulus specific). All original images: original magnification, ×40.
See this image and copyright information in PMC

References

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    1. Locke JE, et al. Normal graft function after pig-to-human kidney xenotransplant. JAMA Surg. 2023;158(10):1106–1108. doi: 10.1001/jamasurg.2023.2774. - DOI - PMC - PubMed

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