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. 2024:2766:9-15.
doi: 10.1007/978-1-0716-3682-4_2.

Human Xenograft Model

Shuang Liu  1
Affiliations

Human Xenograft Model

Shuang Liu. Methods Mol Biol. 2024.

Abstract

Human-SCID grafting is a commonly used technique for the long-term investigation of rheumatoid arthritis (RA) explants. To establish a chimeric immunological system in NOD/SCID mice, RA patient-derived pannus tissue from the synovial membrane, articular cartilage, and bone can be transplanted subcutaneously. Same patient-derived peripheral mononuclear cell chimerism can be successfully achieved by intraperitoneal engraftment. This xenograft model is able to be used for the initial screening of human target-specified biologics.

Keywords: Articular tissue; NOD/SCID mouse; Peripheral mononuclear cell; Synovial invasion; Xenograft rheumatoid arthritis model.

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