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. 2023 Dec;31(Suppl 1):S95-S100.
doi: 10.21101/cejph.a7845.

Cytogenetic analysis of coke oven workers in Eastern Slovakia

Vincent Sedlák  1 , Anton Bujňák  2 , Andrej Gajdoš  2 , Dagmar Gajdošová  2 , Janka Poráčová  1 , Mária Konečná  1 , Jozef Fejér  3 , Daniela Gruľová  3 , Hedviga Vašková  1 , Marta Mydlárová Blaščáková  1
Affiliations
Free article

Cytogenetic analysis of coke oven workers in Eastern Slovakia

Vincent Sedlák et al. Cent Eur J Public Health. 2023 Dec.
Free article

Abstract

Objective: Our study aimed to evaluate the extent of polycyclic aromatic hydrocarbon (PAH) exposure in coke oven workers from Eastern Slovakia by cytogenetic analysis of human peripheral lymphocytes.

Methods: A total of 81 peripheral blood samples were collected from PAH-exposed workers (mean age 45.84 ± 9.73 years) and 30 samples constituted the control group (41.93 ± 15.39 years). The samples were processed using routine cytological analysis. Conventional cytogenetic analysis of human peripheral lymphocytes has been used to evaluate the effects of PAHs.

Results: Comparison of the aberrant cells in the total exposed with the controls showed a significant difference (p < 0.05). A high level of significance (p < 0.001) was observed when comparing the gaps between the exposed group and the control group. There was a significant difference (p < 0.01) in aberrant cells and chromatid breaks (p < 0.05) in the GR1 working subgroup compared with the control group. The results of the correlation analysis did not show a significant relationship between the length of occupational exposure and the frequency of aberrant cells (r = 0.071, p = 0.529). Similarly, no association was observed between smoking among coke plant workers and the frequency of aberrant cells (r = 0.117, p = 0.538).

Conclusion: Cytogenetic analysis showed an increased frequency of chromosomal aberrations in coke oven workers in Eastern Slovakia.

Keywords: aromatic hydrocarbons; cancer; coke oven workers; cytogenetic; lymphocytes.

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