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Meta-Analysis
. 2024 Jan;21(1):e14628.
doi: 10.1111/iwj.14628.

Meta-analysis of the impact of laser interstitial hyperthermia on wound healing complications in brain tumors

Pinrui Yu  1 , Yiran Yang  2
Affiliations
Meta-Analysis

Meta-analysis of the impact of laser interstitial hyperthermia on wound healing complications in brain tumors

Pinrui Yu et al. Int Wound J. 2024 Jan.

Retraction in

Abstract

High-grade gliomas (HGGs) may be amenable to the neurosurgical technique known as laser interstitial thermal therapy (LITT), which delivers thermal energy to interstitial brain injuries and wounds with pinpoint accuracy. The purpose of this extensive meta-analysis was to evaluate the effects of LITT on wound complications among patients who have brain tumours. Diverse conclusions emerge from a systematic review of pertinent studies, necessitating a comprehensive examination. The meta-analysis, performed utilizing the meta library provided by the R package meta, reveals an initial significant overall effect (RR: -2.1262, 95% CI [-2.7466, -1.5059], p < 0.0001) accompanied by considerable heterogeneity among studies (I2 = 61.13%). Following analyses that specifically examined the incidence of wounds, a complex correlation was found (RR: 0.0471, 95% CI [0.0264, 0.0842], p < 0.0001), indicating that LITT has a discernible but insignificant effect on the occurrence of wounds. Although the meta-analysis emphasizes a notable decrease in wound complications subsequent to LITT treatment, additional research is warranted due to constraints in standardized reporting, data accessibility, and small sample sizes. The results of this study underscore the need for exhaustive protocols to analyse wound complications in patients with brain tumours undergoing LITT.

Keywords: brain tumours; infected wounds; wound complications; wound healing.

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Conflict of interest statement

Declared as none.

Figures

FIGURE 1
FIGURE 1
Systematic flowchart overview of the literature screening process employed in meta‐analysis.
FIGURE 2
FIGURE 2
Comprehensive analysis: tumour types and wound complications in LITT studies.
FIGURE 3
FIGURE 3
Initial proportion meta‐analysis of wound complications. (A) Forest Plot. (B) Funnel Plot.
FIGURE 4
FIGURE 4
Subsequent binary outcome meta‐analysis of wound incidences. (A) Forest Plot. (B) Funnel Plot.
See this image and copyright information in PMC

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