Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2024 Apr;47(4):970-971.
doi: 10.1038/s41440-024-01579-w. Epub 2024 Jan 25.

Effects of esaxerenone, a nonsteroidal mineralocorticoid receptor blocker, independent of urinary sodium/potassium ratio and salt intake

Affiliations
Editorial

Effects of esaxerenone, a nonsteroidal mineralocorticoid receptor blocker, independent of urinary sodium/potassium ratio and salt intake

Satoshi Morimoto et al. Hypertens Res. 2024 Apr.
No abstract available

Keywords: Aldosterone; Angiotensin receptor blocker; Hypertension; Mineralocorticoid receptor blocker; Urinary albumin-creatinine ratio.

PubMed Disclaimer

Comment on

References

    1. Shibata S, Nagase M, Yoshida S, Kawarazaki W, Kurihara H, Tanaka H, et al. Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease. Nat Med. 2008;14:1370–6. - DOI - PubMed
    1. Shibata S, Mu S, Kawarazaki H, Muraoka K, Ishizawa K, Yoshida S, et al. Rac1 GTPase in rodent kidneys is essential for salt-sensitive hypertension via a mineralocorticoid receptor-dependent pathway. J Clin Invest. 2011;121:3233–43. - DOI - PubMed - PMC
    1. Katsuya TIY, Uchiyama K, Nishikawa T, Hirano K, Kato M, Fukui T, et al. Exploratory study on the relationship between urinary sodium/potassium ratio, salt intake, and the antihypertensive effect of esaxerenone: the ENaK Study. Hypertens Res. 2024 https://doi.org/10.1038/s41440-023-01519-0 .
    1. Jackson CE, MacDonald MR, Petrie MC, Solomon SD, Pitt B, Latini R, et al. Associations of albuminuria in patients with chronic heart failure: findings in the ALiskiren Observation of heart Failure Treatment study. Eur J Heart Fail. 2011;13:746–54. - DOI - PubMed
    1. Courand PY, Harbaoui B, Becle C, Mouly-Bertin C, Lantelme P. Plasma NT-proBNP mirrors the deleterious cardiovascular and renal continuum in hypertension. Eur J Prev Cardiol. 2017;24:452–9. - DOI - PubMed

LinkOut - more resources