Plant sources, extraction techniques, analytical methods, bioactivity, and bioavailability of sulforaphane: a review

Abstract

Sulforaphane (SFN) is an isothiocyanate commonly found in cruciferous vegetables. It is formed via the enzymatic hydrolysis of glucoraphanin by myrosinase. SFN exerts various biological effects, including anti-cancer, anti-oxidation, anti-obesity, and anti-inflammatory effects, and is widely used in functional foods and clinical medicine. However, the structure of SFN is unstable and easily degradable, and its production is easily affected by temperature, pH, and enzyme activity, which limit its application. Hence, several studies are investigating its physicochemical properties, stability, and biological activity to identify methods to increase its content. This article provides a comprehensive review of the plant sources, extraction and analysis techniques, in vitro and in vivo biological activities, and bioavailability of SFN. This article highlights the importance and provides a reference for the research and application of SFN in the future.

Keywords: Bioactivity; Bioavailability; Extraction technology; Plant source; Sulforaphane.

Fig. 1

Roles of sulforaphane in the regulation of cellular processes associated with its anti-oxidant, anti-cancer, anti-inflammatory, anti-obesity, anti-obesogenic, anti-diabetic, and antimicrobial properties