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. 2024 Apr;43(4):777-784.
doi: 10.1007/s10096-024-04766-2. Epub 2024 Jan 26.

Evaluation of the MTS™ aztreonam-avibactam strip (Liofilchem) on New Delhi metallo-β-lactamase-producing Enterobacterales

Cardot Martin Emilie  1 , Colombier Marie Alice  2 , Gougeon Marine  3 , Eric Farfour  3 , Annabelle Pourbaix  2 , Laurent Dortet  4 , Limousin Lucie  3 , Vasse Marc  3   5
Affiliations

Evaluation of the MTS™ aztreonam-avibactam strip (Liofilchem) on New Delhi metallo-β-lactamase-producing Enterobacterales

Cardot Martin Emilie et al. Eur J Clin Microbiol Infect Dis. 2024 Apr.

Abstract

The combination of ceftazidime-avibactam (CAZ-AVI) and aztreonam (ATM) is used to treat MBL-producing Enterobacterales-related infections. The new combination aztreonam-avibactam (AZA) is currently in development. We compared results obtained with the new MIC test strip (MTS) AZA (Liofilchem) with broth microdilution method (BMD) on 41 MBL-producing Enterobacterales from 41 clinical samples. The MTS AZA was also compared to combination testing method using CAZ-AVI and ATM strips. Compared to BMD, categorical agreement (CA) was 100%. Compared with combination testing method, CA was 97.6%. The MTS AZA can be used to determine MICs levels of AZA or CAZ-AVI/ATM combinations.

Keywords: Aztreonam-avibactam; Carbapenemase; Enterobacterales; Strip.

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