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Comment
. 2024 Feb 12;42(2):175-177.
doi: 10.1016/j.ccell.2024.01.003. Epub 2024 Jan 25.

Unlocking CAR T cell potential: Inosine-induced stemness and enhanced potency

Xingying Zhang  1 , Haoyi Wang  2
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Free article
Comment

Unlocking CAR T cell potential: Inosine-induced stemness and enhanced potency

Xingying Zhang et al. Cancer Cell. .
Free article

Abstract

Adenosine (Ado) drives immune suppression in the tumor microenvironment. In this issue of Cancer Cell, Klysz et al. investigate Ado-mediated immunosuppression. Overexpression of Ado deaminase (ADA-OE), metabolizing Ado to inosine (INO), induces stemness and improves CAR T cell functionality. Likewise, exposure to INO enhances CAR T cells' function and induces stemness features.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • Inosine induces stemness features in CAR-T cells and enhances potency.
    Klysz DD, Fowler C, Malipatlolla M, Stuani L, Freitas KA, Chen Y, Meier S, Daniel B, Sandor K, Xu P, Huang J, Labanieh L, Keerthi V, Leruste A, Bashti M, Mata-Alcazar J, Gkitsas N, Guerrero JA, Fisher C, Patel S, Asano K, Patel S, Davis KL, Satpathy AT, Feldman SA, Sotillo E, Mackall CL. Klysz DD, et al. Cancer Cell. 2024 Feb 12;42(2):266-282.e8. doi: 10.1016/j.ccell.2024.01.002. Epub 2024 Jan 25. Cancer Cell. 2024. PMID: 38278150 Free PMC article.

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