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Review
. 2024 Jan 27;24(1):23.
doi: 10.1007/s10238-023-01264-1.

mRNA vaccine boosters and impaired immune system response in immune compromised individuals: a narrative review

Alberto Boretti  1
Affiliations
Review

mRNA vaccine boosters and impaired immune system response in immune compromised individuals: a narrative review

Alberto Boretti. Clin Exp Med. .

Abstract

Over the last 24 months, there has been growing evidence of a correlation between mRNA COVID-19 vaccine boosters and increased prevalence of COVID-19 infection and other pathologies. Recent works have added possible causation to correlation. mRNA vaccine boosters may impair immune system response in immune compromised individuals. Multiple doses of the mRNA COVID-19 vaccines may result in much higher levels of IgG 4 antibodies, or also impaired activation of CD4 + and CD8 + T cells. The opportunity for mRNA vaccine boosters to impair the immune system response needs careful consideration, as this impacts the cost-to-benefit ratio of the boosters' practice.

Keywords: CD4 + T cells; CD8 + T cells; COVID-19; IgG 4 antibodies; Vaccines.

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Conflict of interest statement

The author declares no potential conflicts of interest for the research, authorship, and/or publication of this article.

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