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. 2024 Jan;14(1):e12327.
doi: 10.1002/clt2.12327.

Clinical characteristics of allergic bronchopulmonary mycosis caused by Schizophyllum commune

Tsuyoshi Oguma  1 , Takashi Ishiguro  2 , Katsuhiko Kamei  3   4 , Jun Tanaka  1 , Junko Suzuki  5 , Akira Hebisawa  5 , Yasushi Obase  6 , Hiroshi Mukae  6 , Takae Tanosaki  7 , Shiho Furusho  8 , Koji Kurokawa  8 , Kentaro Watai  9 , Hiroto Matsuse  10 , Norihiro Harada  11 , Ai Nakamura  11 , Takuo Shibayama  12 , Rie Baba  13 , Kentaro Fukunaga  14 , Hisako Matsumoto  15 , Hisano Ohba  16 , Susumu Sakamoto  17 , Shinko Suzuki  18 , Shintetsu Tanaka  19 , Takahiro Yamada  20 , Akira Yamasaki  21 , Yuma Fukutomi  9 , Yoshiki Shiraishi  1 , Takahito Toyotome  3   22 , Koichi Fukunaga  7 , Terufumi Shimoda  23 , Satoshi Konno  24 , Masami Taniguchi  9 , Katsuyoshi Tomomatsu  1 , Naoki Okada  1 , Koichiro Asano  1 ; Japan ABPM Research Program
Affiliations

Clinical characteristics of allergic bronchopulmonary mycosis caused by Schizophyllum commune

Tsuyoshi Oguma et al. Clin Transl Allergy. 2024 Jan.

Abstract

Background: Allergic bronchopulmonary mycosis (ABPM) is an allergic disease caused by type I and type III hypersensitivity to environmental fungi. Schizophyllum commune, a basidiomycete fungus, is one of the most common fungi that causes non-Aspergillus ABPM.

Objective: Herein, we attempted to clarify the clinical characteristics of ABPM caused by S. commune (ABPM-Sc) compared with those of allergic bronchopulmonary aspergillosis (ABPA).

Methods: Patients with ABPM-Sc or ABPA were recruited from a nationwide survey in Japan, a multicenter cohort, and a fungal database at the Medical Mycology Research Center of Chiba University. The definition of culture-positive ABPM-Sc/ABPA is as follows: (1) fulfills five or more of the 10 diagnostic criteria for ABPM proposed by Asano et al., and (2) positive culture of S. commune/Aspergillus spp. in sputum, bronchial lavage fluid, or mucus plugs in the bronchi.

Results: Thirty patients with ABPM-Sc and 46 with ABPA were recruited. Patients with ABPM-Sc exhibited less severe asthma and presented with better pulmonary function than those with ABPA (p = 0.008-0.03). Central bronchiectasis was more common in ABPM-Sc than that in ABPA, whereas peripheral lung lesions, including infiltrates/ground-glass opacities or fibrotic/cystic changes, were less frequent in ABPM-Sc. Aspergillus fumigatus-specific immunoglobulin (Ig)E was negative in 10 patients (34%) with ABPM-Sc, who demonstrated a lower prevalence of asthma and levels of total serum IgE than those with ABPM-Sc positive for A. fumigatus-specific IgE or ABPA.

Conclusions: Clinical characteristics of ABPM-Sc, especially those negative for A. fumigatus-specific IgE, differed from those of ABPA.

Keywords: Aspergillus; Schizophyllum commune; allergic bronchopulmonary aspergillosis; allergic bronchopulmonary mycosis; asthma.

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Conflict of interest statement

The authors have no conflicts of interest to declare.

Figures

FIGURE 1
FIGURE 1
Peripheral eosinophil counts (A) and total serum IgE levels (B) among the cases of ABPM‐Sc negative or positive for A. fumigatus‐specific IgE (n = 10 and 19, respectively) and ABPA (n = 46). The number of cases with less than 1000 IU/mL in total IgE concentration was 8 (80%), 3 (16%), and 17 (37%) in ABPM‐Sc negative or positive for A. fumigatus‐specific IgE and ABPA, respectively. ABPM‐Sc, ABPM culture positive for S. commune; ABPA, allergic bronchopulmonary aspergillosis; Ig, immunoglobulin.
See this image and copyright information in PMC

References

    1. Ishiguro T, Takayanagi N, Kagiyama N, Shimizu Y, Yanagisawa T, Sugita Y. Clinical characteristics of biopsy‐proven allergic bronchopulmonary mycosis: variety in causative fungi and laboratory findings. Intern Med. 2014;53(13):1407‐1411. 10.2169/internalmedicine.53.2230 - DOI - PubMed
    1. Rosenberg M, Patterson R, Mintzer R, Cooper BJ, Roberts M, Harris KE. Clinical and immunologic criteria for the diagnosis of allergic bronchopulmonary aspergillosis. Ann intern med. 1977;86(4):405‐414. 10.7326/0003-4819-86-4-405 - DOI - PubMed
    1. Agarwal R, Chakrabarti A, Shah A, et al. Allergic bronchopulmonary aspergillosis: review of literature and proposal of new diagnostic and classification criteria. Clin Exp Allergy. 2013;43(8):850‐873. 10.1111/cea.12141 - DOI - PubMed
    1. Chowdhary A, Agarwal K, Kathuria S, Gaur SN, Randhawa HS, Meis JF. Allergic bronchopulmonary mycosis due to fungi other than Aspergillus: a global overview. Crit Rev Microbiol. 2013;40(1):30‐48. 10.3109/1040841x.2012.754401 - DOI - PubMed
    1. Chowdhary A, Randhawa HS, Gaur SN, et al. Schizophyllum commune as an emerging fungal pathogen: a review and report of two cases. Mycoses. 2013;56(1):1‐10. 10.1111/j.1439-0507.2012.02190.x - DOI - PubMed

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