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. 2024 Jan 24:17:259-273.
doi: 10.2147/IDR.S437920. eCollection 2024.

Antimicrobial Resistance Patterns of Staphylococcus Aureus Isolated at a General Hospital in Vietnam Between 2014 and 2021

Nguyen Van An #  1 , Le Ha Long Hai #  2   3 , Vu Huy Luong  4   5 , Nguyen Thi Ha Vinh  5   6 , Pham Quynh Hoa  7 , Le Van Hung  5   7 , Nguyen Thai Son  1 , Le Thu Hong  1 , Dinh Viet Hung  8 , Hoang Trung Kien  9 , Minh Nhat Le  10   11 , Nguyen Hoang Viet  12 , Duc Hoang Nguyen  13 , Ngai Van Pham  14 , Ta Ba Thang  15 , Tran Viet Tien  16 , Le Huy Hoang  17
Affiliations

Antimicrobial Resistance Patterns of Staphylococcus Aureus Isolated at a General Hospital in Vietnam Between 2014 and 2021

Nguyen Van An et al. Infect Drug Resist. .

Abstract

Purpose: Staphylococcus aureus is a commensal bacteria species that can cause various illnesses, from mild skin infections to severe diseases, such as bacteremia. The distribution and antimicrobial resistance (AMR) pattern of S. aureus varies by population, time, geographic location, and hospital wards. In this study, we elucidated the epidemiology and AMR patterns of S. aureus isolated from a general hospital in Vietnam.

Methods: This was a cross-sectional study. Data on all S. aureus infections from 2014 to 2021 were collected from the Microbiology department of Military Hospital 103, Vietnam. Only the first isolation from each kind of specimen from a particular patient was analyzed using the Cochran-Armitage and chi-square tests.

Results: A total of 1130 individuals were diagnosed as S. aureus infection. Among them, 1087 strains were tested for AMR features. Most patients with S. aureus infection were in the age group of 41-65 years (39.82%). S. aureus isolates were predominant in the surgery wards, and pus specimens were the most common source of isolates (50.62%). S. aureus was most resistant to azithromycin (82.28%), erythromycin (82.82%), and clindamycin (82.32%) and least resistant to teicoplanin (0.0%), tigecycline (0.16%), quinupristin-dalfopristin (0.43%), linezolid (0.62%), and vancomycin (2.92%). Methicillin-resistant S. aureus (MRSA) and multidrug-resistant (MDR) S. aureus were prevalent, accounting for 73.02% and 60.90% of the total strains respectively, and the strains isolated from the intensive care unit (ICU) had the highest percentage of multidrug resistance (77.78%) among the wards.

Conclusion: These findings highlight the urgent need for continuous AMR surveillance and updated treatment guidelines, particularly considering high resistance in MRSA, MDR strains, and ICU isolates. Future research focusing on specific resistant populations and potential intervention strategies is crucial to combat this rising threat.

Keywords: Hanoi; Staphylococcus aureus; Vietnam; antimicrobial resistance; methicillin-resistant S. aureus; multidrug resistance.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Antimicrobial resistance of S. aureus isolated from ICU (intensive care unit) and nonICU between 2014 and 2021.
Figure 2
Figure 2
(A) Overall resistance pattern of Staphylococcus aureus isolates from 2014 to 2021, (B) resistance pattern of Staphylococcus aureus isolates from 2014 to 2021 in different wards, (C) overall trend of MRSA and MSSA isolates from 2014 to 2021, and (D) trend of MRSA isolates from 2014 to 2021 in different wards.
Figure 3
Figure 3
Prevalence of MDR of MRSA and MSSA isolated from 2014 to 2021.
Figure 4
Figure 4
Antimicrobial resistance of MRSA and MSSA isolated from 2014 to 2021.
See this image and copyright information in PMC

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