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. 2024 Jan 16;5(1):3-6.
doi: 10.14744/hf.2023.2023.0010. eCollection 2024.

Changing trends in the etiology of liver transplantation in Turkiye: A multicenter study

Mesut Akarsu  1 , Suleyman Dolu  1 , Murat Harputluoglu  2 , Sezai Yilmaz  2 , Murat Akyildiz  3 , Genco Gencdal  3 , Kamil Yalcin Polat  4 , Dinc Dincer  5 , Haydar Adanir  5 , Ilker Turan  6 , Fulya Gunsar  6 , Zeki Karasu  6 , Hale Gokcan  7 , Sedat Karademir  8 , Gokhan Kabacam  8 , Meral Akdogan Kayhan  9 , Murat Kiyici  10 , Murat Taner Gulsen  11 , Yasemin Balaban  12 , Ahmet Bulent Dogrul  13 , Ali Senkaya  6 , Zeynep Melekoglu Ellik  7 , Fatih Eren  10 , Ramazan Idilman  7
Affiliations

Changing trends in the etiology of liver transplantation in Turkiye: A multicenter study

Mesut Akarsu et al. Hepatol Forum. .

Abstract

Background and aim: This study aimed to identify the indications for liver transplantation (LT) based on underlying etiology and to characterize the patients who underwent LT.

Materials and methods: We conducted a multicenter cross-sectional observational study across 11 tertiary centers in Turkiye from 2010 to 2020. The study included 5,080 adult patients.

Results: The mean age of patients was 50.3±15.2 years, with a predominance of female patients (70%). Chronic viral hepatitis (46%) was the leading etiological factor, with Hepatitis B virus infection at 35%, followed by cryptogenic cirrhosis (24%), Hepatitis C virus infection (8%), and alcohol-related liver disease (ALD) (6%). Post-2015, there was a significant increase in both the number of liver transplants and the proportion of living donor liver transplants (p<0.001). A comparative analysis of patient characteristics before and after 2015 showed a significant decline in viral hepatitis-related LT (p<0.001), whereas fatty liver disease-related LT significantly increased (p<0.001).

Conclusion: Chronic viral hepatitis continues to be the primary indication for LT in Turkiye. However, the proportions of non-alcoholic fatty liver disease (NAFLD) and ALD-related LT have seen an upward trend over the years.

Keywords: Etiology; HBV; NAFLD; liver transplantation.

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Conflict of interest statement

The authors have no conflict of interest to declare.

Figures

Figure 1
Figure 1
Live and cadaveric liver transplant before January 2015 and after January 2015.
Figure 2
Figure 2
Indications for liver transplantation before January 2015 and after January 2015.
See this image and copyright information in PMC

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