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. 2024 Jan;102(1):e25287.
doi: 10.1002/jnr.25287.

The cortical thickness of tricenarian cocaine users assembles features of an octogenarian brain

Leonardo Melo Rothmann  1   2   3 , Lucca Pizzato Tondo  2 , Wyllians Vendramini Borelli  2 , Nathalia Bianchini Esper  4 , Eduardo Tavares Portolan  2   5 , Alexandre Rosa Franco  4   6   7 , Mirna Wetters Portuguez  2   3   5 , Pedro Eugênio Ferreira  2 , Augusto Martins Lucas Bittencourt  2 , Ricardo Bernardi Soder  2   5 , Thiago Wendt Viola  2   3   5 , Jaderson Costa da Costa  2   3   5 , Rodrigo Grassi-Oliveira  1   2   3   5
Affiliations

The cortical thickness of tricenarian cocaine users assembles features of an octogenarian brain

Leonardo Melo Rothmann et al. J Neurosci Res. 2024 Jan.

Abstract

It has been suggested that substance use disorders could lead to accelerated biological aging, but only a few neuroimaging studies have investigated this hypothesis so far. In this cross-sectional study, structural neuroimaging was performed to measure cortical thickness (CT) in tricenarian adults with cocaine use disorder (CUD, n1 = 30) and their age-paired controls (YC, n1 = 30), and compare it with octogenarian elder controls (EC, n1 = 20). We found that CT in the right fusiform gyrus was similar between CUD and EC, thinner than the expected values of YC. We also found that regarding CT of the right inferior temporal gyrus, right inferior parietal cortex, and left superior parietal cortex, the CUD group exhibited parameters that fell in between EC and YC groups. Finally, CT of the right pars triangularis bordering with orbitofrontal gyrus, right superior temporal gyrus, and right precentral gyrus were reduced in CUD when contrasted with YC, but those areas were unrelated to CT of EC. Despite the 50-year age gap between our age groups, CT of tricenarian cocaine users assembles features of an octogenarian brain, reinforcing the accelerated aging hypothesis in CUD.

Keywords: aging; cocaine; cortical thinning; frontal lobe; structural neuroimaging; temporal lobe.

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