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Review
. 2024 Jan 29;24(1):26.
doi: 10.1007/s10238-023-01291-y.

Macrophages and angiogenesis in human lymphomas

Domenico Ribatti  1 , Roberto Tamma  2 , Tiziana Annese  2   3 , Giuseppe Ingravallo  4 , Giorgina Specchia  5
Affiliations
Review

Macrophages and angiogenesis in human lymphomas

Domenico Ribatti et al. Clin Exp Med. .

Abstract

A link exists between chronic inflammation and cancer and immune cells, angiogenesis, and tumor progression. In hematologic malignancies, tumor-associated macrophages (TAMs) are a significant part of the tumor microenvironment. Macrophages are classified into M1/classically activated and M2/alternatively activated. In tumors, TAMs are mainly constituted by M2 subtype, which promotes angiogenesis, lymphangiogenesis, repair, and remodeling, suppressing adaptive immunity, increasing tumor cell proliferation, drug resistance, histological malignancy, and poor clinical prognosis. The aim of our review article is to define the role of TAMs and their relationship with the angiogenesis in patients with lymphoma reporting both an analysis of main published data and those emerging from our studies. Finally, we have discussed the anti-angiogenic approach in the treatment of lymphomas.

Keywords: Angiogenesis; Anti-angiogenesis; Lymphoma; Tumor-associated macrophages.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Fig. 1
Fig. 1
Immunohistochemical staining of CD68, CD163, and C34 in GBC- (A–C) and ABC-DLBCL (D–F) samples, scale bar 60 µm
Fig. 2
Fig. 2
Immunohistochemical staining of CD68, CD163, and C34 in healthy (CTRL) (A–C) and MALT (D–F) samples. Scale bar 60 µm
Fig. 3
Fig. 3
Immunohistochemical staining of CD68, CD163, and C34 in healthy (A–C) and FL at grades 1 (FL1) (D–F), 2 (FL2) (G–I), and 3A (FL3) (L–N) samples. Scale bar 60 µm
Fig. 4
Fig. 4
Immunohistochemical staining of CD68, CD163 and C34 in CHL REL (A–C) and RESP (D–F) samples. Scale bar 60 µm
See this image and copyright information in PMC

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