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Meta-Analysis
. 2024 Jan 1;25(1):287-298.
doi: 10.31557/APJCP.2024.25.1.287.

Correlation between rs1800871, rs1800872 and rs1800896 Polymorphisms at IL-10 Gene and Lung Cancer Risk

Mohammad Vakili  1 , Ahmad Shirinzadeh-Dastgiri  2 , Reza Ershadi  2 , Seyed Alireza Dastgheib  3 , Amirmasoud Shiri  4 , Maryam Aghasipour  5 , Maedeh Barahman  6 , Mohammad Manzourolhojeh  7 , Kazem Aghili  8 , Hossein Neamatzadeh  9 , Elahe Akbarian  10
Affiliations
Meta-Analysis

Correlation between rs1800871, rs1800872 and rs1800896 Polymorphisms at IL-10 Gene and Lung Cancer Risk

Mohammad Vakili et al. Asian Pac J Cancer Prev. .

Abstract

Background: The tumorigenesis of lung cancer is complicated, and genetic factor may have the role in the malignant transformation of lung cells. IL-10 gene polymorphisms have been evaluated for their potential roles in lung cancer. However, those studies results are controversial. To clarify the effects of IL-10 rs1800871, rs1800872 and rs1800896 polymorphisms on the risk of lung cancer, a meta-analysis was performed with eligible individual studies.

Methods: Eligible publications were gathered by retrieving PubMed, Web of Science, Embase, Wan Fang, and CNKI up to September 01, 2023. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of such association.

Results: A total of 23 studies, including 5950 patients with lung cancer and 8046 healthy controls, were identified in this meta-analysis. Overall, there was no a significant association between the rs1800871, rs1800872 and rs1800896 polymorphisms at IL-10 gene and susceptibility to lung cancer globally when all studies in the pooled into this meta-analysis. Stratified analysis by ethnicity showed that rs1800872 polymorphism was associated with lung cancer among Asians and Caucasians. However, no significant association was identified between the rs1800871 and rs1800896 and risk of lung cancer.

Conclusions: Pooled data showed that IL-10 rs1800871, rs1800872 and rs1800896 polymorphisms were not associated with lung cancer globally. Future well-designed large case-control studies with different ethnicities are recommended.

Keywords: Meta-analysis; Polymorphism; interleukin 10; lung neoplasms.

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Figures

Figure 1
Figure 1
Flow Diagram of the Study Selection Process
Figure 2
Figure 2
Forest Plots for the Association of IL-10 Polymorphism with Lung Cancer Risk. A: rs1800871 (allele model: T vs. C); B: rs1800872 (homozygote model: CC vs. AA) ; and C: rs1800896 (heterozygote model: GA vs. AA)
Figure 3
Figure 3
Begg’s Funnel Plots of IL-10 rs1800896 Polymorphism and Lung Cancer Risk for Publication bias Test under the Heterozygote Model (GA vs. AA). Before (blue) and after (red) ‘’Trim-and-Fill’’ method
See this image and copyright information in PMC

References

    1. Mehrabi N, Moshtaghioun SM, Neamatzadeh H. Novel mutations of the chrna3 gene in non-small cell lung cancer in an iranian population. Asian Pac J Cancer Prev. 2017;18(1):253–5. - PMC - PubMed
    1. Jafari-Nedooshan J, Moghimi M, Zare M, Heiranizadeh N, Morovati-Sharifabad M, Akbarian-Bafghi MJ, et al. Association of promoter region polymorphisms of il-10 gene with susceptibility to lung cancer: Systematic review and meta-analysis. Asian Pac J Cancer Prev. 2019;20(7):1951–7. - PMC - PubMed
    1. Jafari M, Dastgheib SA, Ferdosian F, Mirjalili H, Aarafi H, Noorishadkam M, et al. Proportion of hematological cancer patients with sars-cov-2 infection during the covid-19 pandemic: A systematic review and meta-analysis. Hematol Transfus Cell Ther. 2022;44(2):225–34. - PMC - PubMed
    1. Peravali M, Joshi I, Ahn J, Kim C. A systematic review and meta-analysis of clinical characteristics and outcomes in patients with lung cancer with coronavirus disease 2019. JTO Clin Res Rep. 2021;2(3):100141. - PMC - PubMed
    1. Asadian F, Nataj MG, Neamatzadeh H, MİRjalİLİ H, VakİLİ M, DastgİRİ AS, et al. A meta-analysis for prevalence of lung cancer patients with sars-cov-2 infection during the covid-19 pandemic. Eurasian Journal of Medicine and Oncology. 2022;6(1):73–82.

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